| Influence of Danshen Injection on airway inflammation and CD4^＋CD25^＋ regulatory T cells of asthmatic rats |
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| 作者姓名： | Keying Xue Yongming Zhou Shengdao Xiong Weining Xiong Dan Li |
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| 作者单位： | [1]Department of Respiratology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China [2]Department of Research and Applying Stem Cell Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022,China |
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| 摘 要： | Objective： To investigate the influence of Danshen Injection on airway inflammation and CD4^＋CD25^＋ regulatory T cells（CD4^＋CD25^＋ Tr） of asthmatic rats, and elucidate the possible mechanism of Danshen Injection in treatment of asthma. Methods： 30 Wister rats were randomly divided into control group, asthma group and Danshen Injection treated group. Bronchoalveolar lavage fluids （BALF） were collected, and cytology studies were conducted. Lung tissues were obtained and pathologic analyses were done with hematoxylin and eosin stain （HE）. Flow cytometry was used to detect the CD4^＋CD25^＋ Tr ratio in peripheral blood mononuclear cells （PBMCs）. Results： Total cell, the percentage of lymphocytes, neutrophils and eosinophils （Eos） in BALF of Danshen Injection-treated group were lower than that in asthma group （P〈0.05, P〈0.01）. Compared with asthma group, less infiltration of inflammatory cells in lung tissues was observed in Danshen Injection-treated group. CD4^＋CD25^＋ Tr of asthma group was lower than that of control and Danshen Injection treated group （P〈0.05）. Conclusion： Danshen Injection can suppress airway inflammation of asthmatic rats, probably by increasing the number of CD4^＋CD25^＋ Tr.
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| 关 键 词： | 炎症 T细胞 哮喘 丹参注射液 |
| 收稿时间： | 2006-03-15 |
Influence of Danshen Injection on airway inflammation and CD4+ CD25+ regulatory T cells of asthmatic rats |
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| Keying Xue,Yongming Zhou,Shengdao Xiong,Weining Xiong,Dan Li.Influence of Danshen Injection on airway inflammation and CD4+ CD25+ regulatory T cells of asthmatic rats[J].Acta Universitatis Medicinalis Nanjing,2006,20(5):292-295. |
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| Authors: | Keying Xue Yongming Zhou Shengdao Xiong Weining Xiong Dan Li |
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| Abstract: | Objective: To investigate the influence of Danshen Injection on airway inflammation and CD4+CD25+ regulatory T cells(CD4+CD25+ Tr) of asthmatic rats, and elucidate the possible mechanism of Dansben Injection in treatment of asthma.Methods: 30 Wister rats were randomly divided into control group, asthma group and Danshen Injection treated group. Bronchoalveolar lavage fluids (BALF) were collected, and cytology studies were conducted. Lung tissues were obtained and pathologic analyses were done with hematoxylin and eosin stain (HE). Flow cytometry was used to detect the CD4+CD25+ Tr ratio in peripheral blood mononuclear cells (PBMCs). Results: Total cell, the percentage of lymphocytes, neutrophils and eosinophils (Eos) in BALF of Danshen Injection-treated group were lower than that in asthma group (P＜0.05, P＜0.01). Compared with asthma group, less infiltration of inflammatory cells in lung tissues was observed in Danshen Injection-treated group. CD4+CD25+ Tr of asthma group was lower than that of control and Danshen Injection treated group (P＜0.05). Conclusion: Danshen Injection can suppress airway inflammation of asthmatic rats, probably by increasing the number of CD4+CD25+ Tr. |
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| Keywords: | Danshen Injection asthma airway inflammation CD4 CD25 regulatory T cells |
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