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肥厚型心肌病患者血管紧张素转换酶基因缺失多态性研究
引用本文:杨荣,张馥敏,马文珠,谢勇,贾永平.肥厚型心肌病患者血管紧张素转换酶基因缺失多态性研究[J].南京医科大学学报,2000,20(4):272-274.
作者姓名:杨荣  张馥敏  马文珠  谢勇  贾永平
作者单位:南京医科大学第一附属医院心内科!南京210029
基金项目:南京医科大学科技发展基金资助项目!(NY99036)
摘    要:目的 探讨血管紧张素转换酶(ACE)基因插入/缺失(I/D_多态必瑟肥厚型心肌病(HCM)发病的关系。方法 应用PCR技术扩增ACE基因目的片段检测基因多态性。结果 HCM患者与正常对照组的D等位基因频率及DD基因型分布有显著性差异(P〈0.01,P〈0.05),DD基因型HCM患者心脏事件发生率及左室壁厚度明显大于2、ID基因型HCM患者(P〈0.05,P〈0.01),家族性肥厚型心肌病(FHC

关 键 词:肥厚型心肌病  ACE  基因多态性

Angiotensin-converting Enzyme Gene Polymorphisms in Hypertrophic Cardiomyopathy
Yang Rong,Zhang Fumin,Ma Wenzhu,et al..Angiotensin-converting Enzyme Gene Polymorphisms in Hypertrophic Cardiomyopathy[J].Acta Universitatis Medicinalis Nanjing,2000,20(4):272-274.
Authors:Yang Rong  Zhang Fumin  Ma Wenzhu  
Institution:Yang Rong,Zhang Fumin,Ma Wenzhu,et al. Department of Cardiology,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029
Abstract:Objective To investigate the relation between the contribution of the angiotensinconverting enzyme (ACE) gene polymorphisms and hypertrophic cardiomyopathy (HCM). Methods The polymorphism of ACE gene was analyzed with polymerase chain reaction (PCR). Results Dallele frequencies and DD genotype frequencies were higher in HCM patients than those in control subjects (P<0.01,P<0.05). The cardiac events and the degree of left ventricular hypertrophy were also much higher in DD genotype of HCM patients than those in other genotypes of HCM patients (P<0.01,P<0.01). There were no significant differences in Dallele frequencies and DD genotype frequencies between patients of familial HCM(FHCM) and solitary HCM(SHCM)(P>0.05). Conclusion The ACE gene polymorphism are associated with HCM, and DD genotype of ACE gene is a risk factor for cardiac events and left ventricular hypertrophy in HCM patients.
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