PCT、CRP 及 WBC 测定在儿童感染性疾病诊疗中的应用

目的：研究血清降钙素原（ procalcitonin，PCT）、C 反应蛋白（ C-reactive protein，CRP）水平及白细胞（white blood cell，WBC）计数在儿童感染性疾病诊疗中的应用价值。方法：选择2012∽2013年间在阳泉市第三人民医院儿科就诊的157例感染性疾病患儿，按临床诊断分为细菌感染组和非细菌感染组，同时选取79例健康儿童作为对照组，分别进行血清 PCT、CRP 水平测定和全血 WBC 计数。结果：细菌感染组的 PCT、CRP 和 WBC 水平高于对照组，差异具有统计学意义（P 〈0.05）；非细菌感染组的 WBC、CRP 水平高于对照组，差异具有统计学意义（P 〈0.05），而 PCT 差异无统计学意义（P〉0.05）；细菌感染组和非细菌感染组 PCT 差异有统计学意义（P 〈0.05），而 CRP、WBC 差异无统计学意义（P〉0.05）。结论：PCT 可以快速客观地判别儿童感染的类型以及感染严重程度，对临床合理使用抗生素以及疗效观察具有重要的指导意义。

Application of PCT,CRP and WBC Determination in the Treatment of Children with Infectious Diseases

Objective：To explore the application value of procalcitonin（PCT）,C-reactive protein（CRP）level and white blood cell（WBC）counting in the treatment of children with infectious diseases. Methods：157 cases of chil-dren with infectious diseases as the experimental group were divided into bacterial infection group and non-bacterial in-fection group during 2012 ∽ 2013 in The Third People＆#39;s Hospital of Yangquan City in Shanxi Province,while 79 cases of healthy children were selected as the control group. The children were respectively conducted in procalcitonin（PCT）, C-reactive protein（CRP）level and white blood cell（WBC）counting. Results：The procalcitonin（PCT）,C-reactive protein（CRP）level and white blood cell（WBC）counting in bacterial infection group were higher than those in the con-trol group;there was statistical significant difference（P 〈 0. 05）;C-reactive protein（CRP）level and white blood cell （WBC）counting in non-bacterial infection group were higher than the control group. There was statistical significant difference（P 〈 0. 05）;there was no statistical significance（P 〉 0. 05）in procalcitonin,PCT;PCT both in bacterial in-fection group and non-bacterial infection group has statistical significance（P 〈 0. 05）,but there was no statistical signif-icant difference in C-reactive protein（CRP）level and white blood cell（WBC）（P 〉 0. 05）. Conclusion：Procalcitonin （PCT）can objectively and rapidly determine the infection types and severity of the infection. Moreover,there is impor-tant guiding significance in the rational clinical use of antibiotics and curative effect observation.