β_2-MG与尿微量白蛋白及尿微量白蛋白/肌酐在糖尿病肾病早期诊断的应用

目的:探讨β2-MG、尿微量白蛋白(MALB)、尿微量白蛋白/肌酐(MALB/Cr)的检测在糖尿病肾病(DN)的早期诊断及病情进展中的应用价值。方法:把80例糖尿病患者按照尿蛋白阴性、+、++、+++、++++分为5组,用免疫比浊法测定患者血中的β2-GM,尿中的β2-GM和MALB,用苦味酸法测定尿肌酐的含量,并与正常对照组作比较。结果:糖尿病患者尿蛋白阴性时,各项指标与对照组差异有显著性,当尿蛋白出现阳性时,各项指标与对照组差异有显著性。结论:四项指标联合检测更有助于提高DN的早期检出率以及肾脏受损程度,对DN的防治有重要价值。

The Application of β2-MG、MALB、MALB/Cr Detection in Early Diagnosis of Diabetic Nephropathy

Objective To study the clinical value of determination of β2-MG MALB、MALB/Cr in early diagnosis of diabetic nephropathy. Methods 80 cases of diabetic patients were divided into 5 groups which included negative urine protein,positive urine ptotein(urine protein +、++、+++、++++),β2-GM、MALB were measured by immunonephelometry and creatinine were measured by jaffe method.the date were campared with control group. Results DN patient had a higher β2-MG、MALB、MALB/Cr than that of normal people when qualitative tests of urine protein were negative.the levels of every index elevated with the increase of positive urine protein. Conclusin The united determination of urinary β2-GM、MALB、MALB/Cr and serum β2-MG is be helpful to improve positive rate of diabetic mellitus and easimate the part of illness and degsee of injury accurately,there were important clinical value for the index to precaution and treatment of diabetic mellitus.