| 急性冠脉综合征患者易损斑块与血清MMP-9水平的相关性研究 |
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| 引用本文： | 郭士金.急性冠脉综合征患者易损斑块与血清MMP-9水平的相关性研究[J].实用医技杂志,2008,15(11). |
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| 作者姓名： | 郭士金 |
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| 作者单位： | 山东医学高等专科学校,山东,临沂,276002 |
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| 摘 要： | 目的:测定急性冠脉综合征(ACS)患者血清基质金属蛋白酶(MMP-9)水平,与高敏C-反应蛋白进行相关性分析,探讨MMP-9对ACS患者斑块易损性的判断价值。方法:选择ACS患者50例,稳定性心绞痛(SA)26例及30例健康人作为对照,用ELISA法检测血清MMP-9水平,同时检测血清高敏C-反应蛋白(hs-CRP),比较各组患者血清MMP-9、hs-CRP水平变化,并进行相关性分析。结果:ACS组患者外周血清MMP-9、hs-CRP水平明显高于SA组及健康对照组,差异有统计学意义,ACS组内血清MMP-9、hs-CRP水平呈直线正相关。结论:血清MMP-9水平升高与冠状动脉斑块易损性相关,临床检测MMP-9浓度水平的高低可以预测动脉粥样斑块易损性的大小。
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| 关 键 词： | 急性冠脉综合征 基质金属蛋白酶 高敏C-反应蛋白 易损斑块 |
Study of Relativity Between Vulnerable Plaque with Serum Level of Matrix Metall Proteinase-9 in Patients with Acute Coronary Syndromes |
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| Guo Shi-jin.Study of Relativity Between Vulnerable Plaque with Serum Level of Matrix Metall Proteinase-9 in Patients with Acute Coronary Syndromes[J].Journal of Practical Medical Techniques,2008,15(11). |
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| Authors: | Guo Shi-jin |
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| Institution: | Guo Shi-jin(Shandong Medical College; Linyi; Shandong 276002; China); |
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| Abstract: | Objective to observe serum levels of matrix metalloproteinase-9 (MMP-9) and high sensitive C-reactive protein(hs-CRP) in patients with acute coronary syndromes(ACS)and analyzing the relation between themto approach the significance of MMP-9 levels in diagnosis of vulnerable plaque.Methods 50 patients with ACS were studied and 26 patients with stable angina pectoris and 30 cases of age matched healthy individuals were selected as a control.The method of ELISA was used to measure the level of MMP-9,at the sam... |
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| Keywords: | Acute coronary syndrome Matrix metalloproteinase-9 High sensitive C-reactive protein Vulnerable plaque |
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