乙肝病毒携带母亲乳汁中乙肝病毒标志物与HBV-DNA的检测意义

目的 :探讨乙型肝炎产妇产后能否进行母乳喂养。方法 :选择住院分娩的乙型肝炎产妇 32 1例 (肝功能均正常 ) ,其中血清 HBs Ag、HBe Ab(+/ - )、HBc Ab阳性 2 10例为小三阳组 ,HBs Ag、HBe Ag、HBc Ab均阳性 111例为大三阳组。分别留取产后 3d～ 5 d的初乳进行乳汁乙肝病毒标志物 (HBV- M)检测。结果 :两组乳汁中 HBs Ag、HBe Ag、HBc Ab、HBV- DNA阳性率比较 ,差异有显著性意义 (P<0 .0 5 )。结论 :产妇初乳中 HBV- DNA阳性及产妇血清中大三阳者 (HBs Ag、HBe Ag、HBc Ab阳性 )不宜哺乳 ,初乳中单纯 HBs Ag阳性、而 HBV- DNA为阴性的产妇可以哺乳 ,但应给予正确的哺乳指导。

Detection of Hepatitis B Virus Marker and HBV-DNA in the Parturients with Hepatitis B

Objective To study the breast feeding of the parturients with hepatitis B after delivery.Methods 321 parturients with hepatitis B (liver function was normal) were selected and divided into two groups: single positive group(n=210) positive for serum HBsAg and double positive group(n=111) positive for both HBsAg and HBeAg.Hepatitis B virus marker (HBV-M) was detected in the colostrums 3 to 5 days after delivery.Results There was very significant difference in the positive rate of HBsAg, HBeAg, HbcAg and HBV-DNA in the milk between the two groups (P<0.05).Conclusion In terms of the clinical implication of HBV-M,heparturients with the colostrum positive for HBeAg,HBVDNA and those with the serum double positive for HBsAg and HBeAg were not suitable for breast feeding.The parturients with the colostrums positive for HBsAg,but negative for HBV-DNA were suitable for beast feeding.