地中海贫血患者网织红细胞参数检测的临床意义

目的:探讨网织红细胞参数在地中海贫血检测的临床意义。方法:应用XE-2100全自动血细胞分析仪检测了46例地中海贫血患者的网织红细胞百分比(RET%)、网织红细胞绝对值(RET#)、未成熟网织红细胞比率(IRF%)、低荧光强度网织红细胞比率(LFR%)、中荧光强度网织红细胞比率(MFR%)、高荧光强度网织红细胞比率(HFR%)等六项网织红细胞参数,并对检测结果均数进行t检验分析。结果:地中海贫血患者网织红细胞各参数与对照组相比差异具有显著性(P<0.05)。其中网织红细胞百分比、网织红细胞绝对值、未成熟网织红细胞比率、中荧光强度网织红细胞比率、高荧光强度网织红细胞比率显著性增高(P<0.05),LFR%明显下降(P<0.05)。结论:地中海贫血患者网织红细胞中未成熟细胞的增高可能是导致“无效造血”的主要原因之一,同时也能提示贫血的严重程度和更好的评价骨髓的造血功能。

The Clinical Significance of Automated Reticulocyte Multiple Parameters Analysis in Thalassemia Patients

Objective To investigate the clinical significance of automated reticulocyte multiple parameters analysis in thalassemia patients.Methods Automated reticulocyte counting(6 parameters) have been measured in 31 healthy controls and in 46 thalassemia patients with Coulter XE-2100 auto-mated blood cell counter. The parameters include RET%,RET#, IRF, LFR, MFR, HFR.Results There were significant differences between normol subjects and thalassemia patients in all the parameters. RET%、RET#、IRF、MFR、HFR in thalassemia patients were significantly higher than those in healthy controls , otherwise , LFR were obviously decreased in thalassemia patients.Conclusion The increased proportion of immature reticulocytes in thalassemia patients might be one of the main reasons of ineffective erythropoiesis,also,Automated reticulocyte multiple parameters analysis can give information about severity of thalassemia to some distance and help us to evaluate the haematogenesis of the marrow more effectively.