遗传和环境因素对双生子儿童躯体化症状的影响

目的 探讨遗传和环境因素对双生子躯体化症状的影响.方法 运用家长版Achenbach儿童行为评定量表(CBCL)评定双生子的躯体化症状,一般情况问卷、家庭亲密度与适应性量表中文版(FACESII-CV)、一般健康问卷(GHQ-12)等量表调查双生子家庭环境因素.采用Holzinger公式计算双生子躯体化症状的遗传度,SPSS11.5软件包进行统计分析.结果 纳入分析6～16岁的双生子共168对.躯体化症状的遗传度总体为0.86,女性(0.93)高于男性(0.11),男性主要受共享环境因素的影响(0.73);12～16岁组遗传度(0.92)高于6～11岁组(0.84).躯体化症状与GHQ母亲总分相关(r＝0.163,P＜0.05).进行logistic回归分析,结果显示儿童的躯体化症状与其分娩方式和异常分娩及新生儿患病情况等因素有关.结论 除分层后男性儿童躯体化症状主要受共享环境因素的影响外,其余各组均主要受遗传因素的影响.

The effect of genetic and environmental factors on somatic symptoms of children

Objective To explore the effect of genetic and environmental factors on somatic symptoms of children. Methods 168 twin pairs aged 6～16 were collected.Parents completed Achenbach Child Behavior Checklist(CBCL) to evaluate the children's somatic symptoms. FACESII-CV and GHQ-12 were rated by their parents to assess family environment. Using the Holzinger formula to calculate the heritability of somatic symptoms. Using SPSS11.5 software to carry out statistic analysis. Results The total heritability of somatic symptoms was 0.86.It was much higher in girls(0.93) than in boys(0.11),and the boys were mainly influenced by shared environment(0.73).In the group 12～16 years old,the heritability is 0.92,and higher than that of group 6～11 years old(0.84).There was correlation between somatic symptoms and the total GHQ scores of their mother(r＝0.163,P＜0.05). Results of logistic regression indicated that somatic symptoms were related to the way of delivery, abnormal delivery and diseases in newborns. Conclusion Somatic symptoms are mainly effected by shared environmental factors in boys,while in other groups they are all mainly effected by genetic factors.