生理性苍白球钙化患者陈述性记忆的改变

目的 探讨生理性苍白球钙化患者陈述性记忆的改变,为苍白球损伤患者认知功能康复策略的制定提供理论依据.方法 采用韦氏记忆量表中国版进行记忆测试和绘制遗忘曲线的方法对30例生理性苍白球钙化患者(实验组)和30例正常人(对照组)进行对照研究.结果 实验组修订韦氏记忆量表中国版记忆商得分与对照组差异无显著性.2组之间遗忘曲线在时间间隔30 min时差异无显著性,在间隔2h后对照组的记忆保存率为(64.10±0.87)%,实验组为(44.83±1.57)%,差异有显著性.2h点的记忆保存率、9h点记忆保存率与苍白球钙化的体积大小呈负相关(r=-0.743和r=-0.483.P<0.01).1d以后,对照组的遗忘曲线的斜率为-1.95±0.48,实验组为-2.35±0.37,差异无显著性.结论 生理性苍白球钙化患者在陈述性记忆的编码和提取上表现正常,在短期记忆转为长期记忆的记忆巩固过程中出现障碍.

Change of the declarative memory in patients with the calcification of the pallidum

Objective To study change of the declarative memory in patients with the calcification of the pallidum.Method The Chinese version of Wechsler Memory Scale(WMS-RC)test and dmwing forgetting curve were applied in 30 patients and 30 normal controls.Results There was no differences in the WMS-CR test's scores between the two groups.The patients had poorly memory preservation rate at the delays of 2 hours((64.10±0.87)%Vs(44.83±1.57)%,P<0.01),despite normal memory preservation rate over 30 mins and the similar slope after the delays of l day in the forgetting curve.There were negative correlations between the size of calcification and the memory preservation rate at the delays of 2 hours and 9 hours(r=-0.743,r=-0.483.P<0.01).Conclusion The results may reflect the effect of the pallidum on"slower confiolidation"declamtive memory process which aroused by a consequence of the repeated firing of hippocampal-neocortieal connections while the patients have normal memory encoding and retrieval.