| 慢性捆绑应激致大鼠海马CA3区锥体细胞超微结构的变化 |
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| 引用本文： | 廖敏,刘能保,李宏莲,张敏海,杨世民.慢性捆绑应激致大鼠海马CA3区锥体细胞超微结构的变化[J].咸宁医学院学报,2003,17(3):161-163. |
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| 作者姓名： | 廖敏 刘能保 李宏莲 张敏海 杨世民 |
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| 作者单位： | [1]咸宁学院医学院组织胚胎学教研室，湖北咸宁437100 [2]华中科技大学同济医学院组织胚胎学教研室 |
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| 摘 要： | 目的 观察慢性捆绑应激紧张对大鼠海马神经元超微结构的影响。方法 实验组采用捆绑器每天捆绑6h，21d后用透射电镜观察海马CA3区锥体细胞超微结构的变化。结果 实验组海马CA3区锥体细胞细胞器减少，粗面内质网局部扩张井脱颗粒；线粒体肿胀，嵴数量减少；脂褐素增加；核膜内陷，核内外有空泡。结论 慢性捆绑应激导致大鼠海马CA3区锥体细胞退化。
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| 关 键 词： | 慢性捆绑应激 大鼠 海马 CA3区锥体细胞 超微结构 |
| 文章编号： | 1008-0635(2003)03-0161-03 |
| 修稿时间： | 2002年10月20 |
The Ultrastructural Change of the Pyramidal Cells in the Hippocampus CA3 Area of Rats Caused by Chronic Restraint Stress |
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| LIAO Min ,LIU Neng-bao ,LI Hong-lian ,et al.The Ultrastructural Change of the Pyramidal Cells in the Hippocampus CA3 Area of Rats Caused by Chronic Restraint Stress[J].Journal of Xianning Medical College,2003,17(3):161-163. |
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| Authors: | LIAO Min LIU Neng-bao LI Hong-lian |
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| Institution: | LIAO Min 1,LIU Neng-bao 2,LI Hong-lian 2,et al |
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| Abstract: | Objective To observe the effects of chronic restraint stress on ultrastructure of neuron in the hippocampus of rats.Methods The experimental rats were restrained for 6 hours every day.After 21days,the ultrastructural changes of the pyramidal cells in rats'hippocampus CA 3 area were observed with transmission electromicroscopy.Results The organellae of the pyramidal cells in hippocampus CA3 area of the experimental rats decreased.The mitochondria swelled and the number of their crista decreased.The lipofuscin increased in cytoplasm.The nucleus membrane sank inside, and vacuolation degeneration was found in the nucleus and cytoplasm.Conclusion chronic restraint stress leads to the degeneration of hippocampus pyramidal cells. |
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| Keywords: | Chronic restraint stress Hippocampus Pyramidal cells CA 3 area Rat |
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