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黄芩甙对大鼠心肌缺血再灌注所致脂质过氧化损伤的保护作用
引用本文:欧阳昌汉,吴基良,等.黄芩甙对大鼠心肌缺血再灌注所致脂质过氧化损伤的保护作用[J].咸宁医学院学报,2001,15(1):32-34.
作者姓名:欧阳昌汉  吴基良
作者单位:欧阳昌汉(咸宁医学院 药理学教研室,湖北 咸宁 437100)       吴基良(咸宁医学院 药理学教研室,湖北 咸宁 437100)       李立中(咸宁医学院 药理学教研室,湖北 咸宁 437100)
摘    要:目的:研究黄芩甙(baicalin,Bai)对大鼠心肌缺血再灌注所致脂质过氧化损伤的保护作用。方法:采用结扎在体大鼠冠状动脉左前降支造成心肌缺血30min,随后恢复血流行再灌注120min,复制心肌缺血再灌注损伤模型。结果:Bai能不同程度地降低缺血再灌注所引起心肌组织脂质过氧化物丙二醛(MDA)含量升高,提高超氧化物歧化酶(SOD)活性,保护Na^ -K^ -ATP酶活力,降低血清肌酸激酶(CK)和乳酸脱氢酶(LDH)水平。结论:Bai可通过保护脑组织抗氧化酶的活性,抑制脂质过氧化反应,减轻自由基对心肌组织的损害,对缺血再灌注心肌产生保护作用。

关 键 词:黄芩甙  心肌缺血  再灌注损伤  Na^+-K^+-ATP酶  超氧化物歧化酶  丙二醛  脂质过氧化损伤
文章编号:1008-0635(2001)01-0032-03
修稿时间:2000年12月11

Protective Effect of Baicalin on Lipid Peroxidation Induced by Myocardical Postischemic Reperfusion in Rats
OUYANG Chang han,WU Ji liang,LI Li zhong.Protective Effect of Baicalin on Lipid Peroxidation Induced by Myocardical Postischemic Reperfusion in Rats[J].Journal of Xianning Medical College,2001,15(1):32-34.
Authors:OUYANG Chang han  WU Ji liang  LI Li zhong
Abstract:Objective To investigate the effects of baicalin on lipid peroxidation induced by myocardical ischemia reperfusion (I/R) in rats.Methods The experimental model was established by ligation of left anterior descending coronary artery for 30min followed by reperfusion for 120min in anaesthesized rats.Result Baicalin decreased the content of malonaldehyde(MDA),elevated the activity of superoxide dismutase(SOD),suspressed the reduction of Na -K -ATPase activity to certain extent in reperfusion myocardium;decreased lactate dehydrogenase(LDH) and creatine kinase(CK) level in serum in comparison with I/R group.Conclusion Baicalin have protective effects on myocardical postischemic reperfusion injury by enhancing the activity of auti oxidative enzyme subsequently inhibiting lipid peroxidation and attenuating the oxygen free radicals mediated damage to the myocardium.
Keywords:Baicalin  Myocardial ischemia  Reperfusion injury  Na  -K  -ATPase  Superoxide dismutase  Malonaldehyde
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