倒卵叶五加总皂甙抗心律失常作用的实验研究

探讨倒卵叶五加总皂甙对实验性心律失常的影响。方法：采用经动物颈静脉恒 注射的模型，监测哇巴因诱发豚鼠和乌头碱诱发大鼠首次出现室早搏、室速、室颤、心律停搏所用时间并换算成哇巴因和乌头碱的剂量。统计上采用组间ｔ检验。结论ＳＡＯＨ有一定的抗心律失常的作用。

Effect of Saponin of Acanthopanax Obovatus Hoo on Drugs-induced Arrhythmia

Objective To study the effect of saponin of acanthopanax obovatus hoo (SAOH) on ouabain induced arrhythmia in guinea pigs and aconitine induced arrhythmia in rats.Methods The arrhythmia model was produced by constant injecting the drugs into the cervical veins in guinea pigs or rats,the dose of drags for firstly showing of ventricular ectopic beats(VEBS),ventricular tachycardia(VT), ventricular fibrillation(VF) and cardio stopping were measured.Statistics treatment was made with group T test.Result More doses of ouabain or aconitine to induce arrhythmia are needed in SAOH group than those in contrast group.Conclusion SAOH have anti arrhythmic potency on ouabain or aconitine induced arrhythmia.