| 20(S)-9-硝基喜树碱的合成工艺改进 |
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| 引用本文： | 陈莉,周和平,谢志超,吴磊.20(S)-9-硝基喜树碱的合成工艺改进[J].咸宁医学院学报,2006,20(5):405-406. |
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| 作者姓名： | 陈莉 周和平 谢志超 吴磊 |
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| 作者单位： | 咸宁学院药学院,湖北咸宁437100 |
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| 摘 要： | 目的 改进20(S)-9-硝基喜树碱(9-NC)的合成与纯化工艺.方法 以喜树碱(CPT)为原料,经硝化、柱色谱分离提纯制备目标产物9-NC.结果 采用新工艺后,9-NC总收率达到35%.结论 新工艺操作简单,缩短了制备周期,值得推广使用.
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| 关 键 词： | 20(S)-9-硝基喜树碱 制备 纯化 |
| 文章编号： | 1008-0635(2006)05-0405-02 |
| 收稿时间： | 2006-05-23 |
| 修稿时间： | 2006年5月23日 |
Improved Synthesis of 20(S)-9-nitrocamptothecin |
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| CHEN Li, ZHOU He-ping, XIE Zhi-chao, et al.Improved Synthesis of 20(S)-9-nitrocamptothecin[J].Journal of Xianning Medical College,2006,20(5):405-406. |
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| Authors: | CHEN Li ZHOU He-ping XIE Zhi-chao |
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| Institution: | Department of Pharmacology, Xianning College, Xianning Hubei 437100, China |
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| Abstract: | Objective To improve the synthetic process of 20(S)9-nitrocamptothecin(9-NC).Methods The product was synthesized from camptothecin by nitration and purification.Results The total yield reaches 35%.Conclusion This improved synthetic process is simpler,more efficient and save time.It is worth wild using. |
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| Keywords: | 20(S)-9-nitrocamptothecin Preparation Purification |
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