雷氏银盏隔姜灸联合补火生土法干预缓解期溃疡性结肠炎的效果评价

  目的  评价雷氏银盏隔姜灸联合补火生土法治疗缓解期溃疡性结肠炎(ulcerativecolitis, UC)的效果及可能的作用机制。  方法  选择2017年1月—2020年6月衢州市中医医院消化科、肛肠科门诊及住院的73例UC患者，按照随机数字表法分为观察组(36例)和对照组(37例)。观察组采用雷氏银盏隔姜灸联合补火生土法治疗，对照组采用美沙拉嗪治疗，疗程为4周，评价2组干预效果及作用机制。  结果  治疗后观察组疗效优于对照组(Z=2.352，P=0.019)。治疗后观察组主要中医症状积分低于对照组(26.04±5.37)分vs. (32.23±6.45)分，P＜0.05]。治疗后观察组改良梅奥评分低于对照组(5.32±1.07)分vs. (6.75±1.56)分，P＜0.05]。治疗后观察组血清CRP、TNF-α、IL-17水平低于对照组(均P＜0.05)。治疗后观察组NK、CD4+与CD4+/CD8+水平高于对照组，CD8+水平低于对照组(均P＜0.05)。治疗后观察组IgG、IgM水平明显低于对照组(均P＜0.05)。  结论  雷氏银盏隔姜灸联合补火生土法干预治疗缓解期UC的效果明确，其作用机制可能与调节肠道炎症、免疫功能有关。 

Evaluation of the effect of LEI's Yinzhan ginger moxibustion combined with Buhuo Shengtu therapy on ulcerative colitis in the remission stage

  Objective  To evaluate the effect and possible mechanism of LEI's Yinzhan ginger-padded moxibustion combined with Buhuo Shengtu therapy in the treatment of ulcerative colitis (UC) in the remission stage.  Methods  From January 2017 to June 2020, 73 UC patients in the Department of Gastroenterology, Department of Anus and Intestine of Quzhou Hospital of Traditional Chinese Medicine were randomly divided into two groups according to random number table method. The observation group(n=36) was treated with LEI's Yinzhan ginger-padded moxibustion combined with Buhuo Shengtu therapy, whereas the control group(n=37) was treated with mesalazine. The course of treatment was 4 weeks. The intervention effect and mechanism of the two groups were evaluated.  Results  After treatment, the efficacy of the observation group was better than that of the control group (Z=2.352, P=0.019). The symptom score of the observation group was lower than that of the control group (26.04±5.37) scores vs. (32.23±6.45) scores, P < 0.05]. The Mayo score in the observation group was lower than that in the control group (5.32±1.07) scores vs. (6.75±1.56) scores, P < 0.05]. The levels of serum inflammatory factors (CRP, TNF-α and IL-17) were lower in the observation group than in the control group (all P < 0.05). The levels of NK, CD4+ and CD4+/CD8+ were higher in the observation group than in the control group (all P < 0.05). The IgG and IgM values were significantly lower in the observation group than those in the control group (all P < 0.05).  Conclusion  LEI's Yinzhan ginger-padded moxibustion combined with Buhuo Shengtu therapy has a definite effect on the treatment of UC in the remission stage, and its mechanism may be related to the regulation of intestinal inflammation and immune function.