自拟流感方治疗儿童乙型流感的疗效及血清学研究

  目的  观察自拟流感方治疗儿童乙型流感的临床疗效及其对血清学IL-6、γ-干扰素(IFN-γ)的影响。  方法  选择2019年1月—2020年2月就诊于浙江省中西医结合医院儿科门诊符合纳入标准的乙型流感患儿60例，按随机数表法分为观察组及对照组，各30例，2组均予以对症支持治疗的同时，观察组给予口服自拟流感方, 对照组予口服奥司他韦，疗程均为5 d，记录并比较2组组间及治疗前后组内血清IL-6及IFN-γ的差异。  结果  治疗5 d后，观察组脱落2例，对照组脱落1例，观察组总有效率为96.4%，高于对照组的72.4%(P < 0.05)。治疗前2组血清IL-6及IFN-γ水平差异无统计学意义，2组组内治疗前后IL-6及IFN-γ比较差异有统计学意义(均P < 0.05)；治疗后观察组IL-6为0.53(0.36，0.66)ng/L，低于对照组的0.69(0.46，1.37)ng/L，观察组IFN-γ水平为3.47(1.96，5.90)ng/L，低于对照组的5.07(2.38，13.12)ng/L, 差异均有统计学意义(均P < 0.05)。  结论  自拟流感方能有效治疗儿童乙型流感，改善临床症状，并降低血清IL-6、IFN-γ水平，其作用机制可能通过降低IL-6、IFN-γ炎症因子水平来发挥作用。 

Efficacy and serological study of self-designed influenza formula in treating influenza B in children

  Objective  To observe the clinical efficacy of self-made influenza formula in the treatment of influenza B in children and its effect on serological Interleukin 6 (IL-6) and Interferon-γ (IFN-γ).  Methods  Total 60 in the standard cases of children with influenza B were selected from the Pediatric Outpatient of Zhejiang Integrated Traditional and Western Medicine Hospital from January 2019 to February 2020. They were equally divided into observation and control groups according to the random-number table method, 30 cases in each group. Both groups supported symptomatic treatment. At the same time, the observation group was given oral self-made influenza formula and the control group was given oral oseltamivir for 5 days. The serum IL-6 and IFN- γ between the two groups and before and after treatment were recorded and compared.  Results  After 5 days of treatment, 2 cases of leakage were found in the observation group, and 1 case of leakage was found in the control group. The total effective rate of the observation group was 96.4%, higher than the 72.4% in the control group (P < 0.05). Before treatment, no difference in serum IL-6 and IFN-γ levels were found between the two groups, and the differences in IL-6 and IFN-γ before and after treatment were statistically significant (all P < 0.05). After treatment, the IL-6 level in the observation group was 0.53(0.36, 0.66) ng/L, which was lower than that in the control group 0.69(0.46, 1.37) ng/L], and the IFN-γ level in the observation group was 3.47(1.96, 5.90) ng/L, which was lower than that in the control group 5.07(2.38, 13.12) ng/L], with statistically significant differences (all P < 0.05).  Conclusion  Self-designed influenza can effectively treat influenza B in children, improve clinical symptoms, and reduce serum levels of IL-6 and IFN-γ. We speculate that its mechanism may play a role by reducing the levels of IL-6 and IFN-γ inflammatory factors.