308 nm准分子激光联合退白汤治疗白癜风的临床疗效及安全性分析

目的 探讨308 nm准分子激光联合退白汤治疗白癜风的临床疗效及安全性。 方法 选取2017年1月—2018年12月儋州市人民医院收治的白癜风患者112例,将112例白癜风患者按随机数表法分为对照组(56例)和观察组(56例)。对照组给予308 nm准分子激光治疗,观察组在对照组的基础上同时给予退白汤治疗,比较2组治疗后的临床有效率。观察2组患者治疗前后的皮损色素积分、皮肤病生活质量指数(DLQI)评分、外周血T淋巴细胞亚群、血清白细胞介素-2(IL-2)、白细胞介素-6(IL-6)及肿瘤坏死因子-α(TNF-α)水平。 结果 观察组治疗后的总有效率(78.57%vs. 60.71%)明显高于对照组(P<0.05)。治疗后,2组皮损色素积分均明显高于同组治疗前,且观察组皮损色素积分明显高于对照组(均P<0.05)。治疗后,2组DLQI评分均明显低于同组治疗前,且观察组DLQI评分明显低于对照组(均P<0.05)。2组治疗后的CD3+、CD4+及CD4+/CD8+均明显高于同组治疗前,而且观察组治疗后CD3+、CD4+及CD4+/CD8+均明显高于对照组(均P<0.05)。2组治疗后血清IL-2、IL-6及TNF-α水平均明显低于治疗前(均P<0.05)。 结论 308 nm准分子激光联合退白汤治疗白癜风的疗效较好,能够显著抑制炎性因子水平,提高患者生活质量和免疫功能,且安全性较好。 

Clinical efficacy and safety of 308 nm excimer laser combined with Tuibai Decoction in the treatm ent of vitiligo

Objective To investigate the clinical efficacy and safety of 308 nm excimer laser combined with Tuibai Decoction in the treatment of vitiligo. Methods Total 112 patients with vitiligo admitted to Danzhou People's Hospital from January 2017 to December 2018 were randomly divided into control group(n=56) and observation group(n=56). The control group was treated with 308 nm excimer laser, while the observation group was treated with Tuibai Decoction on the basis of the control group. The clinical efficacy of the two groups after treatment was compared. The skin pigmentation score, skin disease quality of life index(DLQI) score, peripheral blood T lymphocyte subsets, serum interleukin-2(IL-2), interleukin-6(IL-6) and tumor necrosis factor-alpha(TNF-alpha) levels were observed before and after treatment in the two groups. Results The total effective rate of the observation group after treatment was significantly higher than that of the control group(78.57% vs. 60.71%, P<0.05). After treatment, the skin pigmentation scores of the two groups were significantly higher than those of the same group before treatment, and the skin pigmentation scores of the observation group were significantly higher than that of the control group(all P<0.05). After treatment, the DLQI scores of the two groups were significantly lower than those of the same group before treatment, and the DLQI scores of the observation group were significantly lower than those of the control group(all P<0.05). The levels of CD3+, CD4+, and CD4+/CD8+ in the two groups after treatment were significantly higher than those before treatment in the same group, and the levels of CD3+, CD4+ and CD4+/CD8+ in the observation group were significantly higher than those in the control group after treatment(all P<0.05). Conclusion Excimer laser(308 nm) combined with Tuibai Decoction has better curative effect on vitiligo, which can significantly inhibit the level of inflammatory factors, improve the life quality and immune function of patients, and has better safety.