老年人内脏脂肪面积与血脂水平及冠心病的相关性研究

目的 探讨内脏脂肪面积与血脂水平及冠心病的相关性。 方法 选取2018年4月安徽广德农村地区参与体检的老年人(年龄≥60岁)共139例,结合当地基层医疗档案仔细询问冠心病病史,将于当地医院确诊为冠心病者57例分为冠心病组(CHD),其余体检者共82例为非冠心病组(NC)。清晨空腹抽取静脉血测定血总胆固醇、甘油三酯、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇水平。嘱受检者免冠、脱鞋、空腹,仅着单衣测量身高体重。随后使用韩国Inbody S10人体成分分析仪,应用生物电阻抗原理测量肥胖相关指标:内脏脂肪面积、体脂率、体脂含量、体质量指数。分析内脏脂肪面积与血脂水平及冠心病的相关性。 结果 CHD组的内脏脂肪面积(92.57±39.29)cm2]及其他肥胖相关指标和血低密度脂蛋白(3.96±0.86)mmol/L]水平均高于NC组。回归分析显示内脏脂肪面积增高者及高低密度脂蛋白血症者发生冠心病的风险增加,分别为NC组的4.052倍及2.348倍。相关性分析显示,内脏脂肪面积与血甘油三酯水平呈正相关。 结论 内脏脂肪面积和低密度脂蛋白与冠心病密切相关,老年冠心病个体中内脏脂肪面积及其他肥胖指标显著高于非冠心病个体,当内脏脂肪面积增加或高低密度脂蛋白血症时,老年人冠心病发病风险明显增高。随着内脏脂肪面积增加,血甘油三酯水平增高。故可利用生物电阻抗法分析老年人肥胖相关指标,结合血脂水平对冠心病的预防及预后进行动态监测。 

The correlation between visceral fat area,lipid level and coronary heart disease in the elderly

Objective To investigate the correlation between visceral fat area, blood lipid level and coronary heart disease. Methods A total of 139 old people(aged ≥ 60 years) participated in physical examination in rural areas of Guangde, Anhui province in April 2018 were selected. Combined with the careful inquiry of the history of coronary heart disease in the local primary medical records, 57 physical examinee diagnosed with coronary heart disease were enrolled into coronary heart disease group(CHD), and the remaining 82 physical examinee were enrolled into the non-coronary heart disease group(NC). Venous blood was drawn on an empty stomach in the morning to determine the levels of total cholesterol, triglyceride, low density lipoprotein cholesterol and high density lipoprotein cholesterol. Ask client to remove crown, shoes, fasting, wearing only single clothing to measure height and weight. The obesity related indexes, visceral fat area, body fat rate, body fat content, body fat, body mass index were measured using Inbody S10 body composition analyzer based on the principle of bioelectrical impedance. The correlation between visceral fat area, lipid level and coronary heart disease were analyzed. Results The levels of visceral fat area, other obesity-related indicators and blood low density lipoprotein cholesterol in the CHD group were higher than those in the NC group. Regression analysis showed that those with increased visceral fat area and those with high low-density lipoprotein cholesterol blood level had an increased risk of coronary heart disease, which was 4.052 times and 2.348 times of that of the NC group, respectively. Correlation analysis showed that visceral fat area was positively correlated with serum triglyceride level. Conclusion Visceral fat area and low density lipoprotein cholesterol are closely related to coronary heart disease. Visceral fat area and other obesity indicators are significantly higher in elderly coronary heart disease individuals than in non-coronary heart disease individuals. When visceral fat area is increased or low density lipoprotein cholesterol is high, the risk of coronary heart disease in the elderly is significantly higher. With the increase of visceral fat area, blood triglyceride level increases. Therefore, the principle of bioelectrical impedance can be used to analyze the related indicators of obesity in the elderly and dynamically monitor the prevention and prognosis of coronary heart disease in combination with the level of blood lipid.