左旋氨氯地平对高血压患者血清PDGF-BB及颈动脉内膜中层厚度的影响研究

目的 探讨左旋氨氯地平对高血压患者血清血小板衍生生长因子-BB (PDGF-BB)的影响及该影响与患者颈动脉内中膜厚度(IMT)之间的关系。 方法 将2014年4月—2016年1月在心血管病门诊就诊的原发性高血压患者随机分为对照组(30例)、左旋氨氯地平组(30例)、利尿剂组(30例)。对照组给予治疗性生活方式干预,左旋氨氯地平组给予治疗性生活方式干预+口服左旋氨氯地平,利尿剂组给予治疗性生活方式干预+口服利尿剂。监测血清PDGF-BB水平及颈动脉IMT,并在治疗前将二者进行相关性分析。比较治疗前及治疗6、12个月后血压、血清PDGF-BB及颈动脉IMT的变化。 结果 治疗前患者血清PDGF-BB值与颈动脉IMT值呈中度正相关。治疗6个月后,仅左旋氨氯地平组血清PDGF-BB较治疗前明显降低,其余两组较治疗前差异无统计学意义。治疗12个月后,对照组血清PDGF-BB较治疗前差异无统计学意义,利尿剂组及左旋氨氯地平组血清PDGF-BB均较前进一步降低,且左旋氨氯地平组血清PDGF-BB比利尿剂组更低。治疗12个月后,对照组颈动脉IMT-与治疗前相比均略有升高;利尿剂组较治疗前差异无统计学意义;左旋氨氯地平组较治疗前明显降低。 结论 左旋氨氯地平可降低高血压患者血清PDGF-BB及颈动脉IMT,且血清PDGF-BB及颈动脉IMT呈中度正相关。左旋氨氯地平可能通过降低血清PDGF-BB降低高血压患者颈动脉IMT。 

Effect of levamlodipine on serum levels of platelet-derived growth factor-BB in patients with essential hypertension and its influence on carotid artery intima-media thickness

Objective To study the effect of levamlodipine on the serum levels of platelet-derived growth factor-BB (PDGF-BB) in patients with essential hypertension and its influence on carotid artery intima-media thickness (IMT). Methods Ninety patients with essential hypertension who were visited in the cardiovascular clinic of the affiliated hospital of Panzhihua university from April 2014 to January 2016 were randomized into control group (n=30), levamlodipine group (n=30) and diuretics group (n=30).All groups received the therapeutic lifestyle interventions, in addition, the levamlodipine group was administered with oral levamlodipine, diuretics group with oral diuretics.The serum levels of PDGF-BB and carotid artery IMT were determined.The serum levels of PDGF-BB and carotid artery IMT were analyzed by linear correlation before treatment.The changes in serum levels of PDGF-BB and carotid artery IMT were compared after 6and 12 months of treatment. Results The serum level of PDGF-BB was moderately positively correlated with carotid artery IMT before the treatment.There were obviously decreased in the serum levels of PDGF-BB of the levamlodipine group after 6 months of treatment as compared with those before the treatment.There were no significant difference in the serum levels of PDGF-BB of the control group and diuretics group after 6 months of treatment as compared with those before the treatment.After 12 months of treatment, there was no significant difference in the serum levels of PDGF-BB of the control group as compared with those before the treatment and after 6 months of treatment.The serum levels of PDGF-BB of both levamlodipine group and diuretics group were evidently decreased as compared with those after 6 months.And the serum levels of PDGF-BB of the levamlodipine group were lower than the diuretics group.After 12 months of treatment, the carotid artery IMT of the control group was increased as compared with that before the treatment.The value in the diuretics group was unchanged;the carotid artery IMT of the levamlodipine group was decreased as compared with that before the treatment and after 6 months of treatment. Conclusion In patients with essential hypertension, Levamlodipine may reduce the serum levels of PDGF-BB and carotid artery IMT, and the serum level of PDGF-BB is moderately positively correlated with carotid artery IMT.Levamlodipine may decline the carotid artery IMT through reducing the serum levels of PDGF-BB of essential hypertension.