| 谷氨酰胺对肝硬化患者血清TNF-α和IL-6水平的影响 |
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| 引用本文： | 项立,胡卫东,龙子义,周永柏,吴东海,龙舟,杨兵.谷氨酰胺对肝硬化患者血清TNF-α和IL-6水平的影响[J].中华全科医学,2012(2):223+300. |
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| 作者姓名： | 项立 胡卫东 龙子义 周永柏 吴东海 龙舟 杨兵 |
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| 作者单位： | 广东省深圳市龙岗中心医院消化内科;广东省深圳市龙岗中心医院影像科 |
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| 摘 要： | 目的探讨谷氨酰胺(Gln)对肝硬化患者血清肿瘤坏死因子α(TNF-α)和白细胞介素-6(IL-6)水平的影响及临床意义。方法将44例肝硬化患者随机分为两组,对照组给予常规治疗,试验组在此基础上还给予口服L-2谷氨酰胺呱仑酸钠颗粒,治疗时间8周。对比两组患者治疗前后血清TNF-α和IL-6水平、肝功能变化及自发性腹膜炎发生率。结果试验组用Gln后血清TNF-α和IL-6水平明显降低,与对照组相比,差异有统计学意义(P<0.05),肝功能有所改善,自发性腹膜炎发生率降低,但与对照组相比,差异无统计学意义。结论谷氨酰胺可以显著降低肝硬化患者血清TNF-α和IL-6水平,有利于改善肝硬化患者的肝损害及降低并发症的发生。
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| 关 键 词： | 谷氨酰胺 肝硬化 肿瘤坏死因子α 白细胞介素-6 |
Effect of Glutamine on Serum Tumor Necrosis Factor-α and Interleukin-6 Levels in Patients with Hepatocirrhosis |
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| Institution: | XIANG Li,HU Wei-dong,LONG Zi-yi,et al.Department of Digestion,Shenzhen Longgang Central Hospital,Guangzhou 518172,Guangdong,China |
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| Abstract: | Objective To observe the changes in serum tumor necrosis factor-α(TNF-α) and interleukin-6(IL-6) after administration of glutamine(Gln) in patients with hepatocirrhosis.Methods Patients with hepatocirrhosis were randomized equally into 2 groups and received standard treatment.Besides,the trial group was given 8 weeks of Gln administration.The serum TNF-α,IL-6 and hepatic function were detected and spontaneous bacterial peritonitis(SAP) was observed in two groups.Results The serum IL-6 and TNF-α of Gln group decreased significantly(P<0.01) in comparison with those of the control group.In Gln group,the functions of liver were improved and the incidence of SAP was lower,but it has no significance(P>0.05).Conclusion Gln may improve the clinical outcomes of patients with hepatocirrhosis probably by decreasing serum IL-8 and TNF-α. |
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| Keywords: | Glutamine Hepatocirrhosis Tumor necrosis factor-α Interleukin-6 |
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