阻塞性睡眠呼吸暂停低通气综合征患者血清瘦素与白细胞介素6的关系研究

目的：探讨阻塞性睡眠呼吸暂停低通气综合征（OSAHS）患者血清瘦素及白细胞介素6（IL-6）水平的变化及其临床意义。方法：选择27例OSAHS患者和28例单纯肥胖者（对照组）,通过多导睡眠呼吸监测仪（PSG）监测整夜7 h以上睡眠过程,次日清晨抽取静脉血使用放射免疫法测血清瘦素、IL-6水平。结果：（1）OSAHS组患者血清瘦素水平明显高于对照组（P〈0.01）;（2）OSAHS组患者血清IL-6水平明显高于对照组（P〈0.01）;（3）OSAHS组患者血清瘦素水平与体重指数（r=0.915,P〈0.01）、颈围（r=0.907,P〈0.01）、睡眠紊乱指数（r=0.398,P〈0.05）呈正相关,而与最低血氧饱和度（r=-0.275,P〉0.05）无关;OSAHS组患者血清IL-6水平与BMI（r=0.633,P〈0.01）、颈围（r=0.682,P〈0.01）、AHI（r=0.693,P〈0.01）呈正相关,而与最低SaO2呈负相关（r=-0.683,P〈0.01）;（4）OSAHS组患者血清瘦素水平与IL-6（r=0.690,P〈0.01）呈正相关。结论：OASHS患者血清瘦素与IL-6水平均比正常人升高,并且与病情严重程度有关;OASHS患者血清瘦素水平可能与IL-6有关。

Study on the relationship between leptin and interleukin-6 in patients with obstructive sleep apnea-hypopnea syndrome

Objective： To explore the changes of leptin and interleukin-6（ IL-6） levels as well as its meaning in patients with obstructive sleep apnea-hypopnea syndrome（ OSAHS）. Methods： 27 patients with OSAHS were chosen as the observed group（ OSAHS group）,and 28 obesity patients as the control group. After monitoring the process of seven-hour-sleeping by Polysomnography（ PSG）,venous blood was drawn for measuring the serum leptin and IL-6 level with radioimmunoassay the next morning. Results：（ 1） The leptin level of the OSAHS group was significantly higher than that of the control group（ P 0. 01）;（ 2） The IL-6 level of the OSAHS group was significantly higher than that of the control group（ P 0. 01）;（ 3） The leptin level of the OSAHS group was positively related to BMI（ r = 0. 915,P 0. 01） and neck circumference（ r = 0. 907,P 0. 01）,AHI（ r = 0. 398, P 0. 05）,but had nothing to do with the lowest SaO 2; the IL-6 level of the OSAHS group was positively related to BMI（ r = 0. 633,P 0. 01） and neck circumference（ r = 0. 682,P 0. 01）,AHI（ r = 0. 693,P 0. 01）, negatively related to the lowest SaO 2（ r =-0. 683,P 0. 01）;（ 4） The leptin level of the OSAHS group was positively related to that of the IL-6（ r = 0. 690,P 0. 01）. Conclusion： Both the leptin and IL-6 level of the patients with OSHAS were not only higher than those of the healthy people,but also related to their severity of disease. The leptin level was possibly related to that of IL-6 of the patients with OSHAS.