红景天对慢性应激导致的抑郁大鼠体质量和摄取糖、水量的影响

目的：探讨红景天对慢性应激（chronic mild stress，CMS）导致的抑郁模型大鼠体质量和摄取糖、水量的影响。方法：70只雄性SD大鼠分为正常对照组（予0．5％羧甲基纤维素钠）、模型对照组、阴性对照模型组（予0．5％羧甲基纤维素钠）、阳性对照模型组（予氟西汀）和红景天低剂量、中剂量、高剂量模型组分别予1．5、3、6g／（kg·d）红景天]。除正常对照组大鼠外，其余6组大鼠给予4周的慢性刺激制备抑郁模型。模型建立成功后，予相直的药物灌胃治疗．每周检测大鼠体质量、1％糖水摄取量和自来水摄取量。结果：经过4周慢性中等强度剌激后，与正常对照组大鼠相比，抑郁模型组大鼠的体质量以及1％糖水摄取量明显降低。灌服药物后．低剂量红景天组大鼠的体质量以及1％糖水摄取量恢复至正常对照组水平。结论：低剂量红景天能够促使抑郁大鼠恢复体质量和糖摄取量。

Effects of Rhodiola rosea on body weight and intake of sucrose and water in depressive rats induced by chronic mild stress

Objective: To explore the effects of Rhodiola rosea on the body weight and the intake of sucrose and water in depressive rats induced by chronic mild stress.dz Methods: A total of 70 male SD rats were divided into seven groups, including normal control group (treated with 0.5% sodium carboxymethycellulose), untreated group, negative control group (treated with 0.5% sodium carboxymethycellulose), positive control group (treated with fluoxetine), low-, medium- and high-dose Rhodiola rosea group (treated with 1.5, 3, 6 g/kg Rhodiola rosea respectively). Except for rats in normal control group, the other sixty rats endured chronic stress for 4 weeks to establish the depression model. After that, rats were administered Rhodiola rosea for 3 weeks. During the whole experiment, the body weight, and sucrose intake, tap water intake of all rats were examined once a week. dz Results: After the termination of the stress regime, compared with the normal control group, the body weight and 1% sucrose intake in depressive rats were decreased. After 3-week Rhodiola rosea treatment, the body weight and 1% sucrose intake increased in rats of the low-dose Rhodiola rosea group and recovered to the level of the normal control group.dz Conclusion: Low-dose Rhodiola rosea can increase the body weight and sucrose intake of depressive rats, making them recover to normal status.