变异型心绞痛证候要素提取及其组合与分布规律

目的:提取变异型心绞痛(variant angina pectoris,VAP)证候要素并分析其证候要素组合与分布规律,探讨VAP的病机特点。方法:收集175例VAP患者病历资料,以基于信息熵的复杂系统分划方法提取证候要素,确定症状贡献度,以受试者工作特征曲线建立诊断阈值,通过阈值辨证结果,分析VAP证候要素组合与分布规律。结果:VAP存在气虚、气滞、血瘀、痰浊、火热、痰热、阴虚、阳虚等证候要素,可有单一证候要素或2个、3个及4个以上证候要素组合类型,气虚、阴虚、气滞、血瘀、痰浊在VAP证候要素分布中出现的频率较高。结论:基于信息熵的复杂系统分划方法可以用于提取证候要素,通过分析证候要素组合与分布规律发现VAP病机复杂,气虚、阴虚、气滞、血痰、痰浊是其主要病机因素。

Extraction, combination and distribution regularity of syndrome elements in patients with variant angina pectoris

Objective:To explore the pathogenesis characteristics of variant angina pectoris(VAP)by extracting its syn- drome elements and analyzing the combination and distribution regularity of the syndrome elements. Methods:One hundred and seventy-five case files of VAP patients were collected.The extraction of syn- drome elements and symptom contribution to syndrome was completed by the partition method of complex system based on entropy theory.Diagnostic threshold was established by receiver operator characteristic curve.According to the results diagnosed by diagnostic criteria for syndrome element with quantitation,the combination and distribution regularity of the syndrome elements in patients with VAP was analyzed. Results:The basic syndrome elements in the patients with VAP were qi deficiency,qi stagnation,blood stasis,phlegm turbidity,phlegm-heat,stagnation-heat,yin deficiency and yang deficiency syndromes.It showed that the combination types of syndrome elements could be made up of one syndrome,two,three, four or more than four syndromes.Qi deficiency,yin deficiency,qi stagnation,blood stasis and phlegm tur- bidity syndromes had the higher frequency than other syndrome elements in the patients with VAP. Conclusion:The partition method of complex system based on entropy theory can be used in extracting the syndrome elements of the patients with VAP.It is found that VAP has complicated pathogenesis according to the combination and distribution regularity of syndrome elements.Qi deficiency,qi stagnation,blood stasis, phlegm turbidity and yin deficiency syndromes are the main syndrome elements.