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三七醇提液对恶性肿瘤肝转移的干预作用
引用本文:陈培丰,刘鲁明,陈震,林胜友,宋伟祥,徐颖扉.三七醇提液对恶性肿瘤肝转移的干预作用[J].中西医结合学报,2006,4(5):500-503.
作者姓名:陈培丰  刘鲁明  陈震  林胜友  宋伟祥  徐颖扉
作者单位:1. 浙江中医药大学第一医院肿瘤科,浙江,杭州,310006
2. 复旦大学肿瘤医院中西医结合科,上海,200032
摘    要:目的:观察三七醇提液对恶性肿瘤肝转移的干预作用。方法:建立肿瘤肝转移模型,观察不同剂量三七醇提液对荷瘤肝转移小鼠生存质量、肿瘤生长和肝转移的影响。结果:三七醇提液可以改善荷瘤肝转移小鼠的全身情况,并具有明显的抑瘤和抗肝转移作用,这种作用又以三七醇提液中、低剂量组更为明显。结论:三七醇提液可改善荷瘤鼠全身情况,并具有抑瘤、抗转移的作用。

关 键 词:三七  肝转移  肿瘤  小鼠
文章编号:1672-1977(2006)05-0500-04
收稿时间:2006-02-04
修稿时间:2006年2月4日

Effects of ethanol extracts of Panax notoginseng on liver metastasis of B16 melanoma grafted in mice
Pei-Feng CHEN,Lu-Ming LIU,Zhen CHEN,Sheng-You LIN,Wei-Xiang SONG,Ying-Fei XU.Effects of ethanol extracts of Panax notoginseng on liver metastasis of B16 melanoma grafted in mice[J].Journal of Chinese Integrative Medicine,2006,4(5):500-503.
Authors:Pei-Feng CHEN  Lu-Ming LIU  Zhen CHEN  Sheng-You LIN  Wei-Xiang SONG  Ying-Fei XU
Institution:1. Department of Oncology, First Hospital, Zhejiang University of Traditional Chinese Medicine, Hangzhou, Zhejiang Province 310006, China; 2. Department of Integrated Traditional Chinese and Western Medicine, Cancer Hospital, Fudan University, Shanghai 200032, China
Abstract:OBJECTIVE: To observe the effects of ethanol extracts of Panax notoginseng on the tumor and the liver metastasis in experimental mice grafted with B16 melanoma. METHODS: B16 melanoma was transplanted in the spleen of C57BL/6 mice. The effects of different doses of ethanol extracts of Panax notoginseng on the inhibition rate of spleen tumors and the liver metastasis were observed respectively. RESULTS: The high-, medium-, and low-doses of the extracts and the interferon-alpha (IFN-alpha) can improve the quality of life of the experimental mice. The weights of spleen tumor were lower in the low- and medium-dose extracts-treated groups and the IFN-alpha-treated group than that in the normal saline (NS)-treated group (P<0.05 or P<0.01). The liver metastasis was less in the low- and medium-dose extracts-treated groups and the IFN-alpha-treated group than that in the NS-treated group (P<0.01). CONCLUSION: The ethanol extracts of Panax notoginseng can improve the quality of life of the experimental mice and inhibit the growth of tumor and the liver metastasis.
Keywords:Panax notoginseng  liver metastasis  tumor  mice
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