| 超微粉体技术对穿心莲药材中穿心莲内酯及脱水穿心莲内酯溶出率的影响 |
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| 引用本文： | 邱蓉丽,李璘,李祥,张海霞,陈建伟.超微粉体技术对穿心莲药材中穿心莲内酯及脱水穿心莲内酯溶出率的影响[J].中西医结合学报,2004,2(6):456-458. |
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| 作者姓名： | 邱蓉丽 李璘 李祥 张海霞 陈建伟 |
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| 作者单位： | 南京中医药大学药学院药物化学教研室,江苏,南京,210029 |
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| 摘 要： | 目的:探讨超微粉碎对穿心莲药材中有效成分溶出率的影响.方法:用高效液相色谱法(high performance liquid chromatography,HPLC)测定穿心莲超微粉与药材120目细粉中穿心莲内酯及脱水穿心莲内酯的溶出率.结果:超微粉药材中穿心莲内酯及脱水穿心莲内酯的溶出率明显增加.结论:超微粉碎可显著提高穿心莲药材中有效成分的溶出率.
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| 关 键 词： | 穿心莲 超微粉碎 穿心莲内酯 |
| 文章编号： | 1672-1977(2004)06-0456-03 |
| 修稿时间： | 2004年5月6日 |
Effect of ultra-fine powder technique on dissolution rates of andrographolide and dehydroandrographolide in Andrographis paniculata |
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| QIU Rong-Li,LI Lin,LI Xiang,ZHANG Hai-Xia,CHEN Jian-Wei.Effect of ultra-fine powder technique on dissolution rates of andrographolide and dehydroandrographolide in Andrographis paniculata[J].Journal of Chinese Integrative Medicine,2004,2(6):456-458. |
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| Authors: | QIU Rong-Li LI Lin LI Xiang ZHANG Hai-Xia CHEN Jian-Wei |
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| Institution: | Department of Medicinal Chemistry, School of Pharmacy, Nanjing University of Traditional Chinese Medicine, Nanjing, Jiangsu Province 210029, China. rongliq@hotmail.com |
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| Abstract: | Objective: To investigate the effects of ultra-fine powder technique on dissolution rates of the components in Andrographis paniculata. Methods: High performance liquid chromatography was employed to determine the concentration of andrographolide and dehydroandrographolide in common powdered or ultra-fine powdered Andrographis paniculata. Results: The dissolution rates of andrographolide and dehydroandrographolide in ultra-fine powdered Andrographis paniculata were higher than those of the general powder. Conclusion: Ultra-fine powder technique promotes the dissolution rates of andrographolide and dehydroandrographolide. |
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| Keywords: | Andrographis paniculata ultra-fine powder technique andrographolide |
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