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清宫止血颗粒对免疫低下小鼠免疫功能的影响
引用本文:吴克明,曾婧,曾南,龙旭,张丽梅,胡春芳.清宫止血颗粒对免疫低下小鼠免疫功能的影响[J].中西医结合学报,2004,2(3):203-204,215.
作者姓名:吴克明  曾婧  曾南  龙旭  张丽梅  胡春芳
作者单位:1. 成都中医药大学妇科教研室,四川,成都610075
2. 成都市计划生育研究所,四川,成都610031
摘    要:目的:探讨具有益气活血、祛瘀止血功能的中药复方制剂清宫止血颗粒的药效学机制.方法:以健康雌性KM小鼠和环磷酰胺致免疫低下的模型小鼠为对象,观察清宫止血颗粒对小鼠单核细胞吞噬功能(采用碳粒廓清法)、2,4-二硝基氯苯(2,4-dinitrochlorobenzene,DNCB)致小鼠迟发性过敏反应以及血清溶血素抗体的影响.结果:(1)清宫止血颗粒能增强免疫低下模型小鼠肝脾对碳粒的廓清能力,低、高剂量组与环磷酰胺组比较有极显著差异(P<0.01),中剂量组与环磷酰胺组比较有显著差异(P<0.05);(2)清宫止血颗粒能增强免疫低下小鼠的细胞免疫,其低、中、高剂量均能增加DNCB致敏的免疫低下小鼠耳的肿胀程度,与环磷酰胺比较均有极显著差异(P<0.01);(3)清宫止血颗粒能提高免疫低下小鼠体内溶血素抗体含量,其高剂量与环磷酰胺比较有统计学意义(P<0.05),其低、中剂量亦有提高溶血素抗体含量的趋势.结论:清宫止血颗粒能增强实验性免疫低下模型小鼠的特异性与非特异性免疫力,可能有助于加快产后与流产后的全身性恢复和子宫复旧.

关 键 词:清宫止血颗粒  米非司酮  免疫学  小鼠  实验
文章编号:1672-1977(2004)03-0203-02
修稿时间:2003年8月25日

Effect of Qinggong Zhixue Granule on low immunity mice
WU Ke-Ming ,ZENG Jing ,ZENG Nan ,LONG Xu ,ZHANG Li-Mei ,HU Chun-Fang.Effect of Qinggong Zhixue Granule on low immunity mice[J].Journal of Chinese Integrative Medicine,2004,2(3):203-204,215.
Authors:WU Ke-Ming  ZENG Jing  ZENG Nan  LONG Xu  ZHANG Li-Mei  HU Chun-Fang
Institution:Department of Gynecology, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province 610075, China.
Abstract:Objective:To probe into the pharmacological mechanism of the Chinese medicinal compound Qinggong Zhixue Granule (QGZXG), which has an effect of replenishing qi to activate blood and expelling stasis to stop bleeding, in treating irregular vaginal bleeding after medical abortion. Methods:Healthy female KM mice and mice with immunodeficiency caused by cytoxan (CTX) were chosen as experimental subjects. The effects of QGZXG on the phagocytization of the mice's monocytes (by using the method of carbon particles expurgation), the delayed type hypersensitivity caused by 2,4-dinitrochlorobenzene (DNCB) and the content of antibody of hemolysin in the mice's serum were observed. Results:(1)QGZXG improved the ability of the liver and spleen of immunodeficient mice to expurgate carbon particles. There was an significant statistical difference between the CTX treated group and the low dose group as well as the high dose group (P<0.01) and a statistical difference between the CTX treated group and the medium dose group (P<0.05). (2)QGZXG boosted the cellular immunity of immunodeficient mice. The ear swelling of mice in low, medium and high dose group was more obvious than that in the CTX treated group, and this difference was significant in statistics (P<0.01). (3)QGZXG raised the content of the antibody of hemolysin in the serum of immunodeficient mice. A statistical difference occurred between the high dose group and the CTX treated group. The low and medium dose also had a tendency of such effect. Conclusion:QGZXG can improve both the specific and non-specific immunity of the immunodeficient mice, and therefore accelerate the recovery of the whole body and endometrium after parturition and abortion. In consequence, it leads to shorter duration and less quantity of vaginal bleeding after medical abortion.
Keywords:Qinggong Zhixue Granule  mifepristone  immunology  laboratory mice
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