构建纳米方剂体系的可能性和必要性

纳米中药研究十多年来取得了卓越的成就。随着纳米技术的飞速进展，我们可以考虑构建新型的纳米方剂体系，采用多孔材料、多层复合颗粒或多功能纳米颗粒组合而成多功能实体等新型纳米技术，在君臣佐使配伍原则指导下，建立包含多种中药有效成分，并且具有控释、缓释、靶向、示踪等功能的新型纳米方剂体系。及时将纳米技术的最新进展引入到中医药研究领域，对深入探讨中医药学的内涵和实质以及新型方剂体系的设计、筛选、应用都具有十分重要的科学意义。

Possibility and necessity of constructing new nanoformula systems of traditional Chinese medicine

The past decade has witnessed the remarkable progress on nanotechnology and nanoherb. With the globally rapid development of nanotechnology, we are considering to construct new nanoformula systems of traditional Chinese medicine （TCM） by using porous materials, multilayered core-shell particles or nanoparticles containing various multifunctional parts. With the compatibility of sovereign, minister, assistant and courier in a formula, new nanoformula systems of TCM will have various advantages, such as containing multiple active species, controlled release, targeting function, and labeling and tracing capabilities. Using the latest breakthroughs of nanotechnology for the modern research of TCM will greatly help enhance the ability to investigate the principles of TCM, and to design, screen and utilize new nanoformula systems of TCM.