银杏内酯对犬脑血流量的影响

目的:观察银杏内酯对犬脑血流量的影响.方法:将麻醉犬随机分为5组,每组4只,溶剂对照组灌胃食用油(1 ml/kg),阳性药物对照组灌胃杏灵颗粒(0.22 g/kg),受试药物各剂量组灌胃银杏内酯(分别为4.86、14.6、43.7 mg/kg),给药后不同时间点分别记录颈内动脉血流量、血压、心电图、心率,并进行对照分析.结果:银杏内酯4.86、14.6、43.7 mg/kg灌胃,对麻醉犬血压、心率无显著影响;14.6及43.7 mg/kg灌胃90 min后使脑血流量显著增加,43.7 mg/kg灌胃150 min后可显著减少脑血管阻力.结论:银杏内酯可降低麻醉犬脑血管阻力,增加脑血流量,不影响心率及血压.

Effects of ginkgolide on cerebral blood flow in dogs

Objective: To observe the effects of ginkgolide (GL) on th e cerebral blood flow in dogs. Methods: Dogs anesthetized with s odium pentobarbital were randomly divided into 5 groups, with 4 dogs in each gro up. Ginkgolide of 4.86, 14.6 and 43.7 mg/kg and Xingling Granule of 0.22 g/k g were administered by gavage to the dogs in each of 4 groups. The dogs in the o ther group were administered with edible oil (1 ml/kg) as control group. The cerebral blood flow, systolic blood pressure, diastolic blood pressure, mea n arterial blood pressure and electro-cardiogram of the dogs were measured at d ifferent times after the administration. Results: Ginkgolide of 4.86, 14.6 and 43.7 mg/kg had no obvious effects on the blood pressure and t he heart rate. Ginkgolide of 14.6 and 43.7 mg/kg increased the cerebral blood fl ow 90 minutes after administration, and ginkgolide of 43.7 mg/kg obvious ly decreased the cerebral vascular resistance 150 minutes after administ ration. Conclusion: Ginkgolide can increase the cerebral blood flow and decrease the cerebral vascular resistance, and it has no obvious effects on blood pressure and heart rate in dogs.