家兔绝经后动脉粥样硬化模型的建立及补肾治疗对其的影响

目的　建立家兔绝经后动脉粥样硬化模型并探讨补肾治疗对其的影响。方法　新西兰家兔分别用去势 ,高脂饲料+免疫损伤 ,去势 +高脂饲料 +免疫损伤三种方法造模 ,12周后检测相关指标。结果　去势 +高脂饲料 +免疫损伤组模型动物改变最明显 ,雌激素水平下降 ,血清胆固醇、三酰甘油等明显升高 (P <0 .0 5) ,并伴血管壁的损害 ;补肾中药能缓解上述改变。结论　新西兰家兔经去势 +高脂饲料 +免疫损伤处理可造成绝经后动脉粥样硬化模型 ,其改变可能与肾虚有一定联系

Study of an animal model of post-menopausal atherosclerosis in rabbit and observation of the effect of herbal formula of tonifying-kidney on it

ObjectiveTo establish an animal model im itating post-menopausal atherosclerosis in rabbit and observe the effect of the herbal formula of tonifying-kidney on this animal model. Methods The New Zealand rabbits were treated with ovariectomy, high choleste rol diet plus immune injury, and both of ovariectomy and high cholesterol diet p lus immune injury respectively. The blood lipid level and the intima and media o f the aorta were observed. ResultsThe rabbits treated with ovariectomy and high cholesterol diet plus immune injury changed markedly a nd had low level of estrogen, high levels of CHOL, TG and dysfunction of the art erial endothelium cells. However, the Chinese herbal formula of tonifying-kidne y could relieve these changes. ConclusionThe New Zeala nd rabbits treated with both of ovariectomy and high cholesterol diet plus immun e injury could result in the changes imitating post-menopausal atherosclerosis, and it could be improved by the treatment of herbal formula of tonifying-kidne y, so we think that the changes of the animal model are related to the deficienc y of the kidney in traditional Chinese medicine.