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| CO2超临界流体萃取前胡药材中白花前胡甲素 | |
| 引用本文： | 刘爱东,侯微,陈雪松,邱智东.CO2超临界流体萃取前胡药材中白花前胡甲素[J].中西医结合学报,2008,6(12):1286-1289. |
| 作者姓名： | 刘爱东 侯微 陈雪松 邱智东 |
| 作者单位： | 1. 长春中医药大学附属医院心血管内科,吉林,长春,130021 2. 中国农业科学院特产研究所,吉林,长春,132109 3. 吉林省创智医药开发有限公司研发部,吉林,长春,130051 4. 长春中医药大学药学院药剂学教研室,吉林,长春,130117 |
| 摘 要： | 目的：采用CO2超临界流体萃取法提取前胡药材中的白花前胡甲素。方法：采用正交实验设计法优选前胡中白花前胡甲素的最佳萃取条件，并与传统提取方法作比较。结果：以白花前胡甲素的提取量为指标，最佳萃取条件为萃取温度60℃、萃取压力20MPa、萃取时间3h。加入夹带剂乙醇后白花前胡甲素提取量增加，且超临界流体萃取法明显高于水煎煮和加热回流法。结论：CO2超临界流体萃取法提取前胡药材中自花前胡甲素的方法可行、可靠。 |
| 关 键 词： | CO2超临界流体萃取 前胡 白花前胡甲素 |
Extraction of praeruptorin A from Radix Peucedani by supercritical fluid extaction-CO_2 |
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| Ai-dong LIU,Wei HOU,Xue-song CHEN,Zhi-dong QIU.Extraction of praeruptorin A from Radix Peucedani by supercritical fluid extaction-CO_2[J].Journal of Chinese Integrative Medicine,2008,6(12):1286-1289. | |
| Authors: | Ai-dong LIU Wei HOU Xue-song CHEN Zhi-dong QIU |
| Institution: | Ai-dong LIU~1 Wei HOU~2 Xue-song CHEN~3 Zhi-dong QIU~4 1.Department of Cardiology,Affiliated Hospital of Changchun University of Traditional Chinese Medicine,Changchun,Jilin Province 130021,China 2.Institute of Special Wild Economic Animal , Plant,Chinese Academy of Agricultural Sciences,Jilin Province 132109,China 3.Department of Research , Development,Chuangzhi Medical Development Company Limited,Jilin Province,Jilin Province 130051,China 4.Department of Pharmaceutics,College of P... |
| Abstract: | Objective： To extract praeruptorin A from Radix Peucedani by supercritical fluid extraction （SFE）-CO2. Methods： After preliminary experiment, three main factors were acquired that could influence the result of SFE-CO2, including the time, pressure and temperature of the extraction. The optimal extraction process was carried out on orthogonal design, and SFE-CO2 was compared with the traditional methods. Results： In the extraction of the praeruptorin A, the best extraction conditions were 60 ℃, 20 MPa, and duration for three hours. As cosolvent alcohol was added, the amount of extraction of the praeruptorin A increased, and the amount of SFE-CO2 extraction was higher than those of decoction and heating reflux. Conclusion： The SFE-CO2 in extracting praeruptorin A from Radix Peucedani is feasible and reliable. |
| Keywords: | chromatography supercritical fluid Peucedanum decursivum praeruptorin A |
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