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肺卫失宣与血管活性肠肽及血栓素B2水平变化的临床研究
引用本文:赵国荣,陈锡军,贺又舜,艾碧琛,王孟清,刘克丽,阳航.肺卫失宣与血管活性肠肽及血栓素B2水平变化的临床研究[J].中西医结合学报,2004,2(5):333-336.
作者姓名:赵国荣  陈锡军  贺又舜  艾碧琛  王孟清  刘克丽  阳航
作者单位:1. 湖南中医学院第一附属医院中医临床基础教研室,湖南,长沙,410007
2. 湖南中医学院第一附属医院急诊科,湖南,长沙,410007
3. 湖南中医学院药学分院,湖南,长沙,410007
摘    要:目的:探索肺卫失宣的病理本质,并为卫分证的辨证提供客观实验指标.方法:按完全随机设计,采用放免法共检测19例卫分证及13例气分证患者血浆血管活性肠肽(vasoactive mtestmal peptide,VIP)、血栓素B2(thromboxane B2,TXB2)浓度,观察不同病位、不同病程阶段卫分证、气分证患者血浆VIP、TXB2水平的变化.结果:血浆VIP水平在卫分证及卫分证热退后不同病程及不同病位与气分证阶段及正常组比较均有显著性差异(P《0.01),而血浆TXB2水平仅在卫分证热退后有显著性差异(P《0.01);不同病位的卫分证间血浆VIP、TXB2水平均无明显差异(P》0.05).结论:VIP可能为反映卫分证实质的客观实验指标及肺卫失宣的物质基础,且与病位无关;TXB2在卫分证热退后才升高,不能作为卫分证早期辨证的依据,气分证同样不升高,其机制有待探讨.

关 键 词:卫分病  血管活性肠肽  血栓素B2
文章编号:1672-1977(2004)05-0333-04
修稿时间:2004年5月16日

Clinical study on relationship between sluggishness of lung-defensive qi and levels of vasoactive intestinal polypeptide and thromboxane B2
ZHAO Guo-Rong,CHEN Xi-Jun,HE You-Shun,AI Bi-Chen,WANG Meng-Qing,LIU Ke-Li,YANG Hang.Clinical study on relationship between sluggishness of lung-defensive qi and levels of vasoactive intestinal polypeptide and thromboxane B2[J].Journal of Chinese Integrative Medicine,2004,2(5):333-336.
Authors:ZHAO Guo-Rong  CHEN Xi-Jun  HE You-Shun  AI Bi-Chen  WANG Meng-Qing  LIU Ke-Li  YANG Hang
Institution:Department of Clinical Basic Traditional Chinese Medicine, The First Affiliated Hospital, Hunan College of Traditional Chinese Medicine, Changsha, Hunan Province 410007, China.
Abstract:Objective:To explore the nature of pathology of sluggishness of lung-defensive qi and to offer objective experimental indexes for weifen syndrome (defensive phase syndrome). Methods: According to the completely random design, the plasma levels of vasoactive intestinal peptide (VIP) and thromboxane B2 (TXB2) of 19 patients with weifen syndrome and 13 patients with qifen syndrome (qi phase syndrome) were detected by radioimmunoassay. The plasma levels of VIP and TXB2 at different stages of weifen syndrome and qifen syndrome were observed. Results: The plasma levels of VIP in weifen syndrome and in the late stage of weifen syndrome increased greatly at different stages as compared to qifen syndrome and the blank group ( P <0. 01), while the plasma level of TXB2 of weifen syndrome was higher only at the late stage than the blank group and qifen syndrome( P <0. 01). As for the levels of VIP and TXB2 in weifen syndrome with different internal organs infected, there was no significant difference( P >0. 05). Conclusion: VIP may be an index reflecting the pathology of weifen syndrome, and it is one of the material foundations of sluggishness of lung-defensive qi, but it has nothing to do with the infected internal organs. The level of TXB2 increases only after the fever of patients with weifen syndrome subsided, so it can not be the basis for diagnosis of the early stage of weifen syndrome. It doesn't increase in qifen syndrome either, the mechanism remains to be further studied.
Keywords:weifen diseases  vasoactive intestinal peptide  thromboxane B2
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