| 自身免疫性垂体炎发病机制的研究进展 |
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| 引用本文： | 陈晓依,赵靖宇,陈树春.自身免疫性垂体炎发病机制的研究进展[J].罕少疾病杂志,2022,29(1):4-6,12. |
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| 作者姓名： | 陈晓依 赵靖宇 陈树春 |
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| 作者单位： | 河北北方学院研究生学院 河北 张家口 075000;河北省人民医院内分泌科 河北 石家庄 050051,华北理工大学研究生学院 河北 唐山 063210,河北省人民医院内分泌科 河北 石家庄 050051 |
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| 摘 要： | 自身免疫性垂体炎(AH)是一种罕见的垂体炎性疾病。其临床表现主要以垂体内分泌异常或炎症压迫为特征,典型症状为头痛、视觉受压、多饮、多尿等,并可伴有其他自身免疫性疾病。尽管进行了大量研究,但AH的发病机制尚未完全阐明。因此本文讨论了最近关于自身免疫性垂体炎的潜在机制的发现,以深刻理解AH发生发展的病理生理过程,并可能为AH的诊断和治疗提供新的方向。
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| 关 键 词： | 垂体炎 IgG4 免疫检查点抑制剂 发病机制 |
Research Progress on the Pathogenesis of Autoimmune Hypophysitis |
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| CHEN Xiao-yi,ZHAO Jing-yu,CHEN Shu-chun.Research Progress on the Pathogenesis of Autoimmune Hypophysitis[J].Journal of Rare and Uncommon Diseases,2022,29(1):4-6,12. |
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| Authors: | CHEN Xiao-yi ZHAO Jing-yu CHEN Shu-chun |
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| Institution: | (Graduate School of Hebei North University,Zhangjiakou 075000,Hebei Province,China;Department of Endocrinology,Hebei Provincial People’s Hospital,Shijiazhuang 050051,Hebei Province,China;Graduate School,North China University of Sicience and Technology,Tangshan 063210,Hebei Province,China) |
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| Abstract: | Autoimmune hypophysitis(AH)is a rare inflammatory disease of the pituitary gland.Its clinical manifestations are mainly characterized by abnormal pituitary secretion or inflammatory compression.The typical symptoms are headache,visual stress,polydipsia,polyuria,etc,and may be accompanied by other autoimmune diseases.Despite extensive research,the pathogenesis of AH has not yet been fully elucidated.This article discusses the recent discoveries about the underlying mechanism of autoimmune hypophysitis,in order to deeply understand the pathophysiological process of the occurrence and development of AH,and may provide a new direction for the diagnosis and treatment of AH. |
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| Keywords: | Hypophysitis IgG4 Immune Checkpoint Inhibitors Pathogenesis |
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