急性冠脉综合征早期血清缺血修饰性白蛋白、高敏C反应蛋白及CXC趋化因子配体16水平检测的意义

目的：探讨急性冠脉综合征（acute coronary syndrome,ACS）患者早期缺血修饰性白蛋白（ischemia modifiedalbumin,IMA）、高敏C反应蛋白（high-sensitivity C-reactive protein,hs-CRP）及CXC趋化因子配体16（CXCL16）血清学筛查的意义。方法：选取93例在胸痛3 h内就诊的患者,即时抽血检测IMA、hs-CRP及CXCL16;根据临床诊断标准,其中63例ACS患者入选ACS组,30例排除ACS的胸痛患者入选对照组;比较两组IMA、hs-CRP及CXCL16水平。结果：ACS组患者血清IMA、hs-CRP及CXCL16水平均显著高于对照组（均P〈0.01）;相关分析显示ACS患者血清IMA水平与hs-CRP及CXCL16之间均呈显著性正相关（r=0.286,P〈0.05;r=0.301,P〈0.05）。结论：IMA、hs-CRP及CXCL16与ACS的发生关系密切,早期联合检测有助于ACS患者的早期诊断及风险评估。

Changes and clinical significance of ischemia modified albumin,high-sensitivity C-reactive protein and CXC ligand 16 in early acute coronary syndrome patients

Objective： To explore the values of the serological screening for the ischemia modified albumin（IMA）,high-sensitivity C-reactive protein（hs-CRP） and CXC ligand 16（CXCL16） in early acute coronary syndrome（ACS） patients.Methods： A total of 93 patients who were admitted to hospital in 3 hours after chest pain occurred were recruited and divided into control group（n = 30） and acute coronary syndrome group（ACS n = 63）,IMA,hs-CRP and CXCL16 were detected by intravenous haemospasia and compared between the two groups.Results： The levels of serum IMA,hs-CRP and CXCL16 in ACS group were increased significantly compared with the control group（all P 0.01）.The results of correlation analysis showed that IMA had a positive correlation with hs-CRP and CXCL16（r = 0.286,P 0.05;r = 0.301,P 0.05）.Conclusion： IMA,hs-CRP and CXCL16 were correlated with ACS,and CXCL16 was probably one of the responsible factors of the high serum IMA and hs-CRP levels.They could be the earliest sensitive indicators to the diagnosis and risk estimation of ACS.