2型糖尿病合并代谢综合征患者血清chemerin水平与超敏C反应蛋白的相关性

目的：探讨2型糖尿病（T2DM）合并代谢综合征（MS）患者血清chemerin水平及其与超敏C反应蛋白（hs-CRP）的关系。方法：选择研究对象88例,其中正常对照组28例,T2DM不合并MS组（非MS组）30例,T2DM合并MS组（MS组）30例。所有研究对象均行口服葡萄糖耐量试验（OGTT）及胰岛素释放试验,并检测血脂、血清chemer-in、hs-CRP等相关生化指标。结果：MS组的血清chemerin水平（86.47±23.61）ng/mL,显著高于正常对照组（60.09±15.32）ng/mL及非MS组（61.16±17.90）ng/mL（均P〈0.01）;MS组血清hs-CRP水平为（2.57±1.64）mg/L,明显高于非MS组的（0.98±0.90）mg/L（P〈0.01）;简单相关分析显示,血清chemerin水平与体质量指数（BMI）、腰围、腰臀比、舒张压、空腹胰岛素（FINS）、餐后2 h胰岛素（PSI）、胰岛素抵抗指数（HOMA-IR）、胰岛素β细胞功能指数（HOMA-β）、三酰甘油及hs-CRP水平呈正相关（P〈0.05）,与空腹血糖、餐后2 h血糖、高密度脂蛋白胆固醇呈负相关（P〈0.01）;多元逐步回归分析显示,腰臀比、舒张压、HOMA-β及hs-CRP是影响血清chemerin水平的独立相关因素（P〈0.05）。结论：T2DM合并MS患者血清chemerin明显升高,血清chemerin水平与hs-CRP相关。

Association of serum chemerin with high sensitive C-reactive protein in type 2 diabetes with metabolic syndrome

Objective： To investigate serum levels of chemerin in patients with type 2 diabetes mellitus（T2DM） with metabolic syndrome（MS）,and to study the association between serum levels of chemerin and highly sensitive C-reactive protein（hs-CRP）.Methods： A total of 88 cases were selected,including 28 healthy subjects and 60 T2DM patients which were divided into MS group and non-MS group according to the diagnostic criteria of MS.Oral glucose tolerance test and insulin releasing test were performed,meanwhile,blood lipid,serum chemerin,hs-CRP and other items were measured.Results： Compared with normal control group and non-MS group,the serum chemerin was significantly increased in MS group（86.47 ± 23.61） vs（60.09 ± 15.32） ng / mL,（86.47 ± 23.61） vs（61.16 ± 17.90） ng / mL,P 0.01,respectively];The serum hs-CRP in MS group was higher than in non-MS group （2.57 ± 1.64） vs（0.98 ± 0.90） mg / L,P 0.01].Serum chemerin level was positively correlated with body mass index（BMI）,waist circumference（WC）,waist hip ratio（WHR）,diastolic blood pressure（DBP）,Fasting insulin（FINS）,postprandial serum insulin（PSI）,HOMA-IR,HOMA-β,triglyceride and hs-CRP,and negatively correlated with fasting plasma glucose（FPG）,postprandial plasma glucose（2hPG）,HDL-C.The multiple regression analysis showed hs-CRP,WHR,DBP and HOMA-β were independent related factors in the influence of the serum chemerin levels.Conclusion： T2DM patients with MS tend to have higher serum chemerin and the level of serum chemerin was associated with hs-CRP.