抗环瓜氨酸肽抗体在类风湿关节炎中的诊断意义

目的:评价抗环瓜氨酸肽抗体(抗CCP抗体)在类风湿关节炎(RA)诊断中的意义及在鉴别类风湿关节炎和其他结缔组织疾病(非RA组)中的意义.方法: 对80例RA患者与45例其他结缔组织疾病患者(弥漫性结缔组织病32例、血清阴性脊柱关节病8例、痛风3例、骨性关节炎2例)检测抗CCP抗体(ELISA法),类风湿因子IgM-RF(散射比浊法).结果:IgM-RF诊断RA的敏感性较抗CCP抗体高(RA 71.3%,抗CCP抗体55%),但抗CCP抗体有更高的诊断特异性(抗CCP抗体91.1%,RF 62.2%).抗CCP抗体和IgM-RF联合检测特异性(93.3%)高于单独检测IgM-RF(P＜0.01).结论:抗CCP抗体是RA良好的血清学诊断指标,与IgM-RF联合检测可进一步提高诊断的准确性,有助于RA与其他结缔组织疾病的鉴别.

Diagnostic significance of anti-cyclic citrullinated peptide antibody in patients with rheumatoid arthritis

Objective: To examine the diagnostic significance of anti-cyclic citrullinated peptide antibody in patients with rheumatoid arthritis and to examine the value of anti-cyclic citrullinated peptide(CCP) antibodies and rheumatoid factor(RF) in differenting patients with rheumatoid arthritis(RA) from other rheumatic diseases.Methods: It was determined that the concentration of the two markers in 80 RA patients and 45 non-RA patients.Anti-cyclic citrullinated peptide antibodies was conduced by enzyme-linked immunosorbent assay(ELISA).IgM-RF was conduced by nephelometry. Results: Sensitivity was higher for RF(71.3%),followed by anti-CCP antibodies(55%).Specificity was higher for anti-CCP antibodies(91.1%),followed by RF(62.2%).The combination of anti-CCP and RF had a high specificity(93.3%). Conclusion: Anti-CCP antibodies was a satisfactory marker for RA.The combination of anti-CCP and RF can raise the diagonostic accuracy.Anti-CCP antibodies was a satisfactory marker in discriminating between RA and other rheumatic diseases.