| 生存素反义寡核苷酸对乳腺癌MCF-7细胞株MMP-2及MMP-9表达的影响 |
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| 引用本文： | 许斌,肖蔚,焦霞,赵燕,蒋小芹,于鸿.生存素反义寡核苷酸对乳腺癌MCF-7细胞株MMP-2及MMP-9表达的影响[J].江苏大学学报(医学版),2011,21(3):203-207,277. |
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| 作者姓名： | 许斌 肖蔚 焦霞 赵燕 蒋小芹 于鸿 |
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| 作者单位： | 1. 泰州市人民医院,普外科,江苏,泰州,225000
2. 泰州市人民医院,病理科,江苏,泰州,225000 |
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| 基金项目： | 南通大学自然科学基金资助项目，泰州市311工程人才基金项目 |
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| 摘 要： | 目的:研究生存素(survivin)反义寡核苷酸(antisense oligodeoxynucleotide,ASODN)对人乳腺癌MCF-7细胞株基质金属蛋白酶(matrix metalloproteinase,MMP)-2及MMP-9表达的影响,以进一步阐明生存素介导乳腺癌浸润及转移的机制.方法:经脂质体介导将生...
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| 关 键 词： | 生存素 反义寡核苷酸 基质金属蛋白酶-2 基质金属蛋白酶-9 乳腺癌 |
Effect of survivin ASODN transfection on the expression of MMP-2 and MMP-9 in human breast cancer cell |
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| XU Bin,XIAO Wei,JIAO Xia,ZHAO Yan,JIANG Xiao-qin,YU Hong.Effect of survivin ASODN transfection on the expression of MMP-2 and MMP-9 in human breast cancer cell[J].Journal of Jiangsu University Medicine Edition,2011,21(3):203-207,277. |
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| Authors: | XU Bin XIAO Wei JIAO Xia ZHAO Yan JIANG Xiao-qin YU Hong |
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| Institution: | XU Bin1,XIAO Wei2,JIAO Xia2,ZHAO Yan2,JIANG Xiao-qin2,YU Hong2(1.Department of General Surgery,2.Department of Pathology,Taizhou People's Hospital,Taizhou Jiangsu 225000,China) |
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| Abstract: | Objective: To investigate the effect of survivin antisense oligodeoxynucleotide(ASODN) transfection on the expression of matrix metalloproteinase(MMP)-2 and MMP-9 in human breast cancer line MCF-7 and to provide experimental foundation for survivin ASODN gene therapy for breast cancer.Methods: Survivin ASODN was transfected into MCF-7 cells through lipofectin.The rate of transfection was detected by fluorescence microscopy.The expressions of survivin,MMP-2 and MMP-9 in transfected cells were detected by RT-... |
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| Keywords: | survivin antisense oligodeoxynucleotide matrix metalloproteinase-2 matrix metalloproteinase-9 breast cancer |
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