2例糖尿病患者颈动脉内膜中层厚度的相关因素分析

目的探讨2型糖尿病患者颈动脉内膜中层厚度的相关因素。方法将91例2型糖尿病患者根据颈动脉内膜中层厚度分为颈动脉内膜正常组（IMT〈1．0mm）、颈动脉内膜增厚组（IMT≥1．0mm）组，分别检测各组血清C反应蛋白（CRP）、空腹哑糖（FBG）、总胆同醇（TC）、甘油三酯（TG）、高密度脂蛋白胆同醇（HDL—C）、低密度脂蛋白胆固醇（LDL—C）、血浆致动脉硬化指数（AIP）、血尿酸（uA）并记录年龄、糖尿病病程、体重指数（BMI）、收缩压（SBP）、舒张压（DBP）、脉压、吸烟史、高血压史、微哑管并发症斑块形成等指标，并进行统计学处理。结果颈动脉内膜增厚组中年龄、TG、AIP、UA、CRP值以及斑块形成、微血管并发症发生率均比颈动脉内膜正常者组显著增高，差异均有统计学意义。Logistic回归分析显示，以IMT为应变量先后人选的变量有年龄（P〈0．01）、甘油三酯（P〈0．05）。结论2型糖尿病患者颈动脉内膜增厚与年龄、TG、AlP、UA、CRP等多因素有关，尤其与年龄、TG密切相关。

Factor analysis 0f carotid intima-media thickness in type 2 diabetics

Objective To discuss the correlation factor of carotid intima-media thickness in the patients with type 2 diabetes mellitus.Methods 91 patients with T2DM,including normal carotid intima-media and thickening carotid intima-media were studied. The physical examinations including measurement of age, diabetes course,body mass index(BMI),blood pressure(SBP and DBP), smoking history, hypertension history, microangiopathy, artery plaque formation etc. Laboratory tests included serum c-reactive protein (CRP), fasting blood glucose(FPG), total cholesterol(TC), triglycerides(TG), HDL-C, LDL-C, atherogenicindexofplasma (AIP) and uric acid.Results The levels of serum TG、AIP、UA、CRP, age and incidence rate of plaque formation microangiopathy in carotid intima-media thickening group were higher than those in normal carotid intima-media group. Stepwise regression analysis of relative factors for carotid intima-media thickness showed that the value of age (P<0.01)and triglyceride(P<0.05) were significantly associated with the carotid intima-media thickness.Conclusion Carotid intima-media thickness may be related to age、TG、AIP、UA and CRP in the patients with type 2 diabetes mellitus,especially to age and TG .