阿托伐他汀联合阿司匹林对急性脑梗死患者脑血流及颈动脉粥样斑块的影响

目的 研究不同剂量阿托伐他汀联合阿司匹林对急性脑梗死患者脑血流指标以及颈动脉粥样斑块的影响。方法 选取2013年4月至2014年4月榆林市星元医院收治的急性脑梗死患者99例为研究对象，随机数表法将患者分为治疗组1、治疗组2及对照组，每组各33例。3组均常规行活血化淤等基础治疗，使用不同剂量的阿托伐他汀联合阿司匹林治疗，分别观察3组的颈动脉内膜中层厚度（IMT）及粥样硬化斑块积分、血清血小板膜表面P选择素（CD62p）、血小板糖蛋白复合物（PAC-1）及超敏C反应蛋白（hs-CRP）变化、血脂变化。结果 治疗后，治疗组1及治疗组2患者IMT及颈动脉斑块积分显著改善（P<0.05）。与治疗前及对照组相比，治疗6个月后，治疗组1及治疗组2患者CD62p、PAC-1及hs-CRP水平显著降低（P<0.05）。治疗后，治疗组1及治疗组2患者血清三酰甘油（TG），总胆固醇（TC）和低密度脂蛋白（LDL）均显著降低（P<0.05）。结论 使用10 mg/d阿托伐他汀联合阿司匹林治疗急性脑梗死患者可抑制血小板活化，减少炎性反应，同时具有稳定颈动脉粥样硬化斑块的作用。

Effects of different doses of Atorvastatin combined with aspirin on cerebral blood flow and carotid atherosclerotic plaques in patients with acute cerebral infarction

Objective To investigate the effect of different doses of Atorvastatin combined with aspirin on cerebral blood flow and carotid atherosclerotic plaques in patients with acute cerebral infarction. Methods 99 cases were randomly divided into the treatment group 1, the treatment group 2 and the control group,with33 cases in each group. different doses of atorvastatin statins combined with aspirin were addnitted in each group.IMT and the level of atherosclerotic plaque integral, CD62p, PAC-1 and hs CRP were compared.Results IMT and carotid artery plaque score of patients in the treatment group 1 and in the treatment group 2 were significantly improved (P<0.05). After treating for 6 months,CD62p, PAC-1 and hs CRP levels of patients in the treatment group 1 and the treatment group 2 significantly reduced (P<0.05) comparing with pre-treatemnt. Changes in the control group were significantly different (P>0.05). Conclusion Using atorvastatin (10 mg/d) of pravastatin combined with aspirin in treatment of acute cerebral infarction patients can inhibit the activation of platelet, reduce inflammation, stability of carotid atherosclerotic plaque making it worthy popularizing in clinical application.