PLA2R基因多态性与成人特发性膜性肾病治疗效果及预后的关系

目的 探讨磷脂酶A2受体(PLA2R)SNP rs35771982位点基因多态性与成人特发性膜性肾病(IMN)治疗效果及预后的关系。方法 选取2017年1月至2018年12月新疆维吾尔自治区人民医院肾内科确诊的60例IMN患者为IMN组,选取同期60例健康体检者作为对照组,比较两组研究对象PLA2R基因单核苷酸多态性(SNP)rs35771982位点的基因型,比较不同基因型IMN患者完全/部分缓解率、复发率、不良反应发生情况,采用二元logistic回归分析PLA2R基因不同基因型与成人IMN患者预后的关系。结果 IMN组患者PLA2R基因SNP rs35771982位点存在GG、GC、CC 3个基因型,GG基因型、G等位基因比例显著低于对照组,CC基因型、C等位基因比例显著高于对照组(P<0.05);CC基因型患者的完全/部分缓解率显著低于GC、GG基因型患者(P<0.05);CC基因型患者的复发率显著高于GC、GG基因型患者(P<0.05);CC基因型患者的血糖异常率显著高于GG基因型患者(P<0.05);CC基因型患者的尿酸异常率显著高于GG、GC基因型患者(P<0.05);logistic回归分析显示,CC基因型是影响IMN患者不良预后的危险因素(OR=6.634, P<0.05)。结论 新疆维吾尔族自治区人群PLA2R基因SNP rs35771982位点的基因多态性可能与成人IMN患者治疗效果、预后相关,且rs35771982位点CC基因型可能是影响IMN患者不良预后的危险因素。

Relationships between PLA2R gene polymorphism and therapeutic effect, prognosis of adult idiopathic membranous nephropathy

Objective To explore the relationships between polymorphism of SNP rs35771982 loci on phospholipase A2 receptor (PLA2R) gene and the therapeutic effect and prognosis of adult idiopathic membranous nephropathy (IMN). Methods 60 IMN patients diagnosed in the Nephrology Department of the People''s Hospital of Xinjiang Uygur Autonomous Region From January 2017 to December 2018 were selected as the IMN group and same time 60 healthy people as the control group. To compare the genotypes at secondary membranous nephropathy (SNP) rs35771982 loci on PLA2R gene in two groups, to compare the complete/partial remission rate, recurrence rate and adverse reactions among different genotypes of IMN patients, and to analyze the relationship between the PLA2R gene different genotypes and the prognosis of adult IMN patients by binary logistic regression. Results There were three genotypes (GG, GC, CC) at SNP rs35771982 loci on PLA2R gene in IMN group, and the frequencies of GG genotype, G allele were significantly lower than that in control group, CC genotype and C allele were significantly higher than that in control group (P<0.05); the complete/partial remission rate of CC genotype was significantly lower than that of GC and GG genotypes (P<0.05); the recurrence rate of CC genotype was significantly higher than that of GC and GG genotypes (P<0.05); the abnormal rate of blood glucose in patients with CC genotype was significantly higher than that in patients with GG genotype(P<0.05); the abnormal rate of uric acid in CC genotype was significantly higher than that in GC and GG genotypes (P<0.05); and logistic regression analysis showed that CC genotype was the risk factor of poor prognosis in IMN patients (or=6.634, P<0.05). Conclusion The polymorphism of SNP rs35771982 loci on PLA2R gene in Xinjiang Uygur Autonomous Region is closely related to the therapeutic effect and prognosis of adult IMN patients, and the CC genotype of rs35771982 may be a risk factor for poor prognosis of IMN patients.