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系统性红斑狼疮患者血清IL-17的水平及临床意义
引用本文:张曲矗,陆进明,徐亮,李志.系统性红斑狼疮患者血清IL-17的水平及临床意义[J].安徽医学,2010,31(1):23-24.
作者姓名:张曲矗  陆进明  徐亮  李志
作者单位:皖南医学院附属弋矶山医院风湿免疫科,芜湖,241000;皖南医学院附属弋矶山医院风湿免疫科,芜湖,241000;皖南医学院附属弋矶山医院风湿免疫科,芜湖,241000;皖南医学院附属弋矶山医院风湿免疫科,芜湖,241000
摘    要:目的探讨IL-17水平变化在系统性红斑狼疮(SLE)发病中的作用。方法应用双抗体夹心酶联免疫吸附试验(ELISA)方法分别测定20例SLE患者,20例非SLE患者以及10例正常对照组血清的IL-17水平。结果20例SLE组与20例非SLE组比较血清IL—17表达水平差异无统计学意义(P〉0.05);20例SLE组血清的IL—17水平显著高于10例正常对照组(192.26±121.72)pg/ml vs(78.05±18.80)pg/ml,P〈0.01];10例SLE活动期与10例稳定期比较差异无统计学意义(P〉0.05);10例SLE活动期血清IL-17水平与临床指标ESR,C3,C4,IgG,抗ds—DNA无显著相关性(P〉0.05);而与SLE疾病活动指数(SLEDAI)号一定程度的相关性(r=0.718,/9〈0.05)。结论IL-17在SLE发病的过程中可能发挥着重要的作用,与疾病活动有一定相关性。

关 键 词:系统性红斑狼疮  白细胞介素17  酶联免疫吸附试验

Level and significance of IL-17 in patients with systemic lupus erythematosus
Zhang Quchu,Lu Jinming,Xu Liang,et al Rheumatological.Level and significance of IL-17 in patients with systemic lupus erythematosus[J].Anhui Medical Journal,2010,31(1):23-24.
Authors:Zhang Quchu  Lu Jinming  Xu Liang  Rheumatological
Institution:Zhang Quchu,Lu Jinming,Xu Liang,et al Rheumatological Department of YiJiShan Hospital of Wannan Medical College,Wuhu 241000,China
Abstract:Objective To investigate the level of IL-17 in patients with systemic lupus erythematosus (SLE) and its pathological role.Methods Enzyme linked immunosorbent assay (ELISA) was used to measure the blood serum level of IL-17 from 20 SLE patients,20 other patients of rheumatology,and 10 healthy persons.Results The expression of IL-17 in SLE group compared with other patients of rheumatology group did not show statistical significance (P> 0.05).The expression of IL-17 in SLE group compared with that in normal c...
Keywords:Systemic lupus erythematosus  Interleukin-17  Enzyme linked immunosorbent assay  
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