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老年2型糖尿病患者血浆同型半胱氨酸与颈动脉内中膜厚度的关系
引用本文:张颖,朱美玲,张杰. 老年2型糖尿病患者血浆同型半胱氨酸与颈动脉内中膜厚度的关系[J]. 安徽医学, 2008, 29(5): 580-582
作者姓名:张颖  朱美玲  张杰
作者单位:安徽省合肥市第一人民医院干部病房,合肥,230061
摘    要:目的探讨老年2型糖尿病患者血浆同型半胱氨酸(Hcy)水平的影响因素,及其与颈动脉内中膜厚度(IMT)之间的关系。方法以120例老年2型糖尿病患者和40例正常对照者为研究对象,测定空腹血糖(FPG)和HbA1C等,采用化学发光法检测血浆Hcy水平,应用颈动脉超声波测定IMT。结果(1)糖尿病组血浆Hcy的平均水平高于正常对照组(P〈0.05),糖尿病组高Hey血症的发病率较正常对照组高(P〈0.05);(2)血浆Hcy水平与体重指数、HbA1C和糖尿病病程与独立相关;(3)高Hcy血症是老年2型糖尿病患者IMT增厚的危险因素(P〈0.01,OR=1.034,95%CI为1.015~1.115)。结论老年2型糖尿病血浆Hcy水平升高,BMI、HbA1C和糖尿病病程是老年2型糖尿病血浆Hcy的独立相关因素。

关 键 词:同型半胱氨酸  2型糖尿病  颈动脉内中膜厚度  血管病变  老年

Relationship between homocysteinemia concentration and carotid intima-media thickness in elder patients with type 2 diabetes
Zhang Ying,Zhu Meiling,Zhang Jie. Relationship between homocysteinemia concentration and carotid intima-media thickness in elder patients with type 2 diabetes[J]. Anhui Medical Journal, 2008, 29(5): 580-582
Authors:Zhang Ying  Zhu Meiling  Zhang Jie
Affiliation:( Department of Ganbu , First People, s Hospital of HeFei ,AnHui 230061 )
Abstract:Objective To survey the factors influencing the plasma homocysteine (Hcy) in elder patients with type 2 diabetes, and investigate the association of tHcy with carotid intima-media thickness(IMT).Methods A total 120 elder patients with type 2 diabetes and 40 normal subjects were screened. Fasting blood samples were collected for measuring FPG and HbA1C et.al。Plasma Hcy level was measured by ELISA,IMT was determined by the duplex ultrasonography.Results (1)The plasma Hcy level in diabetic patients was significantly higher than that in normal control subjects(P<0.05). The prevalence of hyperhomocysteinemia was particularly higher in diabetic patients than that of control subjects(P<0.05).(2) Plasma Hcy was independently correlated to BMI, HbA1C and diabetic duration. (3) IMT was positively related to Hcy(P<0.01,OR =1.034,95%CI为1.015-1.115).Conclusion The elderly patients with type 2 diabetes have Hyper-homocysteinemia, which was affected by BMI, HbA1C and diabetic duration.
Keywords:Homocysteine  Diabetes mellitus  type 2  Carotid intima-media thickness  Vascular disease  The elder
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