孕早期血清维生素A E及氧化应激损伤指标与产妇发生子痫前期的关系

目的 探讨孕早期(孕8～14周)血清维生素A(VA)、维生素E(VE)及氧化应激损伤指标与产妇发生子痫前期(PE)的关系.方法 回顾性分析2017年1月至2019年1月在马鞍山市妇幼保健院定期产检并分娩的5000例产妇的临床资料,根据妊娠期间是否发生PE将产妇分为子痫前期组291例与对照组4709例.比较两组产妇基线资料及孕早期血清VA、VE与氧化应激损伤指标基质金属蛋白酶-9(MMP-9)、胎盘生长因子(PLGF)、总抗氧化能力(T-AOC)]水平差异,采用多因素logistic回归分析产妇发生PE的危险因素.结果 子痫前期组患者血清VA、VE、MMP-9、PLGF、T-AOC水平均低于对照组,差异有统计学意义(P<0.05).多因素logistic回归分析结果显示,VA(OR=1.358,95％CI:1.141～2.376)、VE(OR=1.289,95％CI:1.043～1.983)、MMP-9(OR=1.651,95％CI:1.238～2.865)、PLGF(OR=1.276,95％CI:1.017～2.144)、T-AOC(OR=1.714,95％CI:1.246～2.491)水平下降均为产妇发生PE的独立危险因素(P均<0.05).结论 VA与VE缺乏及相关氧化应激损伤指标水平降低为产妇妊娠早期发生PE的独立危险因素.

Themultivariate logistic regression analysis of effects of serum vitamin A E oxidative stress injury indexes on occurrence of preeclampsia in early pregnancy

Objective To discuss the multivariate logistic regression analysis of the effects of serum VA, VE, oxidative stress injury indexes on the occurrence of preeclampsia in early pregnancy.Methods Retrospective analysis was performed on the clinical data of 5000 pregnant women who underwent regular prenatal examination and delivery in Maternal and Child Health Care Center of Ma''anshan from Jan 2017 to Jan 2019. They were divided into the preeclampsia group (291 cases) and the control group (4709 cases) according to the occurrence of preeclampsia or not during pregnancy. The baseline data, serum VA and VE levels, oxidative stress injury indexes of the pregnant women were recorded and compared; the multivariate logistic regression analysis was used to analyze the risk factors of occurrence of preeclampsia or not during pregnancy. Results The serum VA, VE, MMP-9, PLGF, T-AOC of the preeclampsia group were significantly lower than those of the control group respectively (all P<0.05). The multivariate logistic regression analysis showed that the decrease of VA(OR=1.358, 95%CI:1.141~2.376, VE(OR=1.289, 95%CI:1.043~1.983), MMP-9(OR=1.651, 95%CI:1.238~2.865), PLGF(OR=1.276, 95%CI:1.017~2.144), T-AOC(OR=1.714, 95%CI:1.246~2.491) were independent risk factors of PE during pregnancy (all P<0.05). Conclusions The serum VA and VE levels of pregnant women with PE are significantly lower than those of the normal pregnant women. Lack of VA and VE, decrease of oxidative stress injury index are independent risk factors of PE during pregnancy.