血清HA、LN、CⅣ与肝纤维化病理诊断的关系

目的探讨慢性乙型病毒性肝炎（CHB）患者血清透明质酸（HA）、层黏蛋白（LN）和Ⅳ型胶原（CⅣ）对肝脏炎性损伤和肝纤维化程度的病理诊断意义。方法采用酶免疫法测定120例慢性乙型肝炎患者血清HA、LN、CⅣ水平，对比分析肝脏病理诊断。结果与现行病理诊断标准慢性肝炎分级、分期进行统计学比较，血清HA、LN、CⅣ由G0～G4、S0～S4依次升高，且与肝病分级及分期均呈正相关。结论HA对慢性肝炎病情严重程度判断价值较大．HA和CⅣ有诊断早期肝纤维化的价值，LN可协助诊断中晚期肝纤维化。

The relations between pathology diagnoses of chronic hepatitis B and serums hyaluronic(HA),laminin(LN) and collagen Ⅳ (CIV)

Objective To explore the pathology diagnose significance of the serums HA、LN and CⅣ with inflammation damage and hepatic fibrosis of chronic hepatitis B.Methods In 120 patients with chronic hepatitis B, using the method of ELISA to detect the serum level of hyaluronic, laminin and collagen Ⅳ, and reach hepatic pathology diagnoses through analysis and comparison.Results Compare to existing pathology diagnose standard grading method, serum HA、LN and CⅣ increased inflammation grades from G0 to G4 and fibrosis stages from S0 to S4, respectively.Conclusion Serum HA has some values in finding the severity of hepatitis B, serum HA and CⅣ have ciginifcant value in determine early liver fibrosis, and serum LN is helpful in diagnose of mid to late stage hepatic fibrosis in CHB patients.