| EXPRESSION OF ICAM-1 AND LFA-1 MOLECULES IN RELATION TO RENAL ALLOGRAFT REJECTION IN RATSA |
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| 作者姓名： | Huang Xiaolun Shen Wenlu Li Youping Zhou Zeqing Tan Jiansan |
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| 作者单位： | Huang Xiaolun (黄孝伦)，Shen Wenlu (沈文律)，Li Youping (李幼平)，Zhou Zeqing (周泽清) and Tan Jiansan (谭建三)Department of General Surgery，The First Affiliated Hospital，West China University of Medical Sciences，Chengdu 61 |
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| 摘 要： | ＩＮＴＲＯＤＵＣＴＩＯＮＩｎｒｅｃｅｎｔｙｅａｒｓ，ｓｏｍｅｒｅｓｅａｒｃｈｅｒｓｈａｖｅｓｔｕｄｉｅｄｔｈｅｒｅｌａｔｉｏｎｓｈｉｐｂｅｔｗｅｎｔｈｅｅｘｐｒｅｓｉｏｎｏｆＩＣＡＭ１ｍｏｌｅｃｕｌｅａｎｄｒｅｎａｌｇｒａｆｔｒｅｊｅｃｔｉｏｎｂｏ...
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| 关 键 词： | 同种异体肾移植 排斥反应 动物模型 ICAM-I LFA-1 试验 |
Expression of ICAM-1 and LFA-1 molecules in relation to renal allograft rejection in rats. |
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| Huang Xiaolun,Shen Wenlu,Li Youping,Zhou Zeqing,Tan Jiansan.EXPRESSION OF ICAM-1 AND LFA-1 MOLECULES IN RELATION TO RENAL ALLOGRAFT REJECTION IN RATSA[J].Chinese Medical Sciences Journal,1999,14(3):163-166. |
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| Authors: | X Huang W Shen Y Li Z Zhou J Tan |
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| Institution: | Department of General Surgery, The First Affiliated Hospital, West China University of Medical Sciences, Chengdu 610041. |
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| Abstract: | Objective.The purpose of this study was to assess the renal graft expression of ICAM 1(intercellular adhesion molecule 1) and LFA 1(lymphocyte function associated antigen 1)molecule with relation to graft rejection. Methods.Rat kidney transplantation was performed according to the procedure of Kamada with some modification.Experimental rats were divided into 5 groups.The survival time of recipient rats and function of grafts after renal transplantation were observed.The sections of renal graft were stained for monoclonal antibody ICAM 1 and LFA 1, and then quantification of ICAM 1 and LFA 1 expression was accomplished by computer image analysis. Results.ICAM 1 and LFA 1 increased significantly in the renal allograft rejection group as compared with the non rejection groups(P<0 05). Conclusion.Both biopsy of renal graft and monitoring of ICAM 1 and LFA 1 are useful tools in diagnosing and treating acute rejection. |
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| Keywords: | renal transplantation graft rejection ICAM 1 LFA 1 |
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