APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES |
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| Authors: | Hong Zhao Tie-hu Ye Zhi-yi Gong Yang Xue Zhang-gang Xue Wen-Qi Huang |
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| Institution: | Department of Anesthesiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730. |
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| Abstract: | Objective To assess the efficacy and safety of lomoxicam, one non-steroidal anti-inflammatory drug (NSAID) in patientcontrolled analgesia (PCA) in patients undergoing abdominal surgeries.Methods Thirty-nine patients scheduled for abdominal surgeries were randomly assigned to different PCA treatment groups using either lomoxicam or fentanyl postoperatively. Pain intensity difference (PID) and sum of pain intensity difference (SPID) were used to assess the analgesic efficacy of both drugs during a 24-hour period.Results The analgesic efficacy of lornoxicam is 1/66 of fentanyl, which was shown by SPID value of 3.250 and 3.058,respectively (P ＞ 0.05). Lornoxicam caused fewer adverse events than fentanyl (33% vs. 68%, P ＜ 0.05).Conclusion In clinic, we can use lomoxicam to treat postoperative pain effectively and with less adverse reactions compared with fentanyl. |
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| Keywords: | lornoxicam fentanyl patient-controlled analgesia ABDOMINAL PATIENTS ANALGESIA LORNOXICAM treatment postoperative clinic adverse events value Results lornoxicam used analgesic drugs during period Pain intensity difference Methods |
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