| 血管紧张素转换酶基因插入或缺失多态性与飞行员原发性高血压的相关性 |
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| 引用本文： | 蔡庆,刘红巾,陈涛,朱美财.血管紧张素转换酶基因插入或缺失多态性与飞行员原发性高血压的相关性[J].解放军医学高等专科学校学报,2011(6):1178-1179,F0004. |
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| 作者姓名： | 蔡庆 刘红巾 陈涛 朱美财 |
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| 作者单位： | 解放军空军总医院临床分子生物学研究中心,北京100142 |
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| 基金项目： | “十一五”全军医药卫生科研计划课题（08G045）;空军“十一五”后勤科研计划空后医学领域项目（BKJ09J024） |
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| 摘 要： | 目的探讨血管紧张素转换酶（ACE）基因插入或缺失（I/D）多态性和飞行员原发性高血压的相关性,为飞行员原发性高血压的预防提供依据。方法用聚合酶链反应（PCR）扩增检测48例飞行员原发性高血压患者和50例飞行员健康对照者的ACE基因I/D多态性。结果飞行员高血压组ACE DD基因型（25%）和D等位基因频率（0.47）显著高于健康对照组（分别为8%和0.30）。结论 ACE DD基因型和D等位基因与飞行员原发性高血压病相关。
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| 关 键 词： | 飞行员 血管紧张素转换酶 基因多态性 原发性高血压 |
Relationship between insertion/deletion polymorphism of the angiotensin-converting enzyme gene and essential hypertension in pilots |
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| Cai Qing,Liu Hong-jin,Chen Tao,Zhu Mei-cai.Relationship between insertion/deletion polymorphism of the angiotensin-converting enzyme gene and essential hypertension in pilots[J].Clinical Journal of Medical Officer,2011(6):1178-1179,F0004. |
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| Authors: | Cai Qing Liu Hong-jin Chen Tao Zhu Mei-cai |
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| Institution: | ( Clinical Molecular Biology Research Center, General Hospital of Air Force, PLA, Beijing 100142, China) |
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| Abstract: | Objective To investigate the relationship between insertion/delation （I/D） polymorphism of the angiotensin-converting enzyme （ACE） gene and essential hypertension of pilots and provide an important reference for essential hypertension of pilots. Methods 48 pilots with essential hypertension and 50 healthy control pilots were genotyped for the I/D polymorphism of the ACE gene by the polymerase chain reaction （PCR）. Results It was showed that the genotype DD and D allele frequency of ACE were significantly higher in pilots with essential hypertension （25% and 0.47） than that in healthy control subjects （8% and 0.30）. Conclusion The genotype DD and D allele of ACE were correlated with essential hypertension in pilots. |
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| Keywords: | pilot angiotensin-converting enzyme gene polymorphism essential hypertension |
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