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姜黄素脂质体在大鼠体内药代动力学研究
引用本文:许汉林,孙芸,邵继征,熊利容,张念,黄成刚.姜黄素脂质体在大鼠体内药代动力学研究[J].湖北中医学院学报,2007,9(1):42-43.
作者姓名:许汉林  孙芸  邵继征  熊利容  张念  黄成刚
作者单位:湖北中医学院药学院 湖北武汉430065(许汉林,邵继征,熊利容,张念,黄成刚),新疆医科大学医药学院 新疆乌鲁木齐830054(孙芸)
摘    要:目的研究姜黄素脂质体口服液在大鼠体内的药代动力学行为。并与游离姜黄素溶液进行比较,评价姜黄素脂质体药代动力学特征。方法大鼠灌胃给药,摘眼球取血,HPLC测定血药浓度;采用3P87药代软件模拟房室模型并计算药代动力学参数。结果当姜黄素的给药量1次接近300 mg/kg时,其药代动力学过程为非线性动力学过程。结论姜黄素脂质体口服液比姜黄素混悬液入血速度明显加快,有利于机体的吸收,并且消除减慢,血液中浓度高,在组织中分布广。

关 键 词:姜黄素  姜黄素脂质体  药代动力学
文章编号:24054180
修稿时间:11 20 2006 12:00AM

Study On Pharmacokinetics of the Curcumin Liposomes in Rat
XU Han-lin , SUN Yun, SHAO Ji-zhen ,et al.Study On Pharmacokinetics of the Curcumin Liposomes in Rat[J].Journal of Hubei College of Traditional Chinese Medicine,2007,9(1):42-43.
Authors:XU Han-lin  SUN Yun  SHAO Ji-zhen  
Institution:1. Hubei College of Traditional Chinese Medicine 430065; 2. Xinjiang Medical University ,Wulumuqi 830054
Abstract:Objective: To study the concentration of the curcumin liposomes oral liquid in rat with time changed in comparision of the free curcumin suspension,and then estimate the pharmacokinetic characteristics of the curcumin liposomes.Methods: Drawing the blood from eyeball of rat after oral administration and the blood concentrations were determined by HPLC.Simulating compartment model with software program 3P87 and calculating pharmacokinetics parameters.Results: The pharmacokinetic characteristics were nonlinear when curcumin was 60mg each time.Conclusion: Curcumin liposomes oral liquid is absorbed more rapidly and eliminated more slowly than curcumin suspension,which is also distributed in more tissues and the concentrations in blood is higher.
Keywords:Curcumin liposomes  Curcumin  Pharmacokinetic
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