| 慢性再生障碍性贫血治疗前后骨髓细胞组织化学及超微结构的动态研究 |
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| 引用本文： | 李建华,张圣明,崔为发,白林,刘荣卿,王树庆,薛吉年,胡匡祜.慢性再生障碍性贫血治疗前后骨髓细胞组织化学及超微结构的动态研究[J].潍坊医学院学报,1989(4). |
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| 作者姓名： | 李建华 张圣明 崔为发 白林 刘荣卿 王树庆 薛吉年 胡匡祜 |
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| 作者单位： | 潍坊医学院附属医院中医科，潍坊医学院组胚教研室，潍坊医学院附属医院内科，潍坊医学院组胚教研室，潍坊医学院附属医院中医科，潍坊医学院附属医院中医科，中国科学院生物物理所，中国科学院生物物理所 |
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| 摘 要： | 通过对35例慢性再生障碍性贫血(CAA)患者应用不同方案治疗前后骨髓细胞糖原、细胞色素氧化酶(CCOase)和中性粒细胞碱性磷酸酶(NAP)的显微分光图像分析仪定量分析和超微结构研究,支持了本病是由于骨髓微环境与造血干细胞损伤而引起的学说。同时,对体内酶系统紊乱导致CAA发病过程作了初步阐明,从而提出CAA发病机制新假说。
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| 关 键 词： | 贫血 再生障碍性 骨髓细胞 组织化学 超微结构 发病机制 |
DYNAMIC STUDY OF HlSTOCHEMISTRY AND ULTRASTRUCTURE FROM CHRONIC APLASTlC ANEMIA BONE MARROW CELLS BEFORE AND AFTER THERAPY |
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| Li J ianhua,et al.DYNAMIC STUDY OF HlSTOCHEMISTRY AND ULTRASTRUCTURE FROM CHRONIC APLASTlC ANEMIA BONE MARROW CELLS BEFORE AND AFTER THERAPY[J].Journal of Weifang Medical College,1989(4). |
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| Authors: | Li J ianhua |
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| Institution: | Weifang Medical College |
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| Abstract: | With the before and after therapy in different treatment, 35 cases of chronic aplastic anemia(CAA) bone marrow cells were studied, in cluding glucogen, cytochrome oxidase(CCOase) and neutrophilic granulocytes alkaline phosphatase(NAP) amounts under the microspectroseopic image analyser and transmissional electron microscopy. The results supported the theories which CAA was caused by damaged both the bone marrow microenvi ronment and stem cells. At the same time, we expounded preliminarily that enzyme systems diosorder result in CAA, therefore, we put forward a new hypothesis on the pathogenesis of CAA. |
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| Keywords: | anemia aplastic bone marrow cells histochemistry ultrastructure pathogenesis |
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