| 白血病患者染色体脆性部位的研究 |
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| 引用本文： | 严明仁,张红伟.白血病患者染色体脆性部位的研究[J].潍坊医学院学报,1992,14(2):84-86. |
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| 作者姓名： | 严明仁 张红伟 |
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| 作者单位： | 潍坊医学院生物学教研室，潍坊医学院生物学教研室，潍坊市人民医院，潍坊医学院儿科学教研室，潍坊市人民医院，潍坊医学院生物学教研室 |
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| 摘 要： | 采用低叶酸低小牛血清的培养基,对10例白血病患者和9例正常对照的外周血淋巴细胞染色体畸变率和脆性部位进行了研究。结果在实验组中观察910个中期分裂相有118个畸变位点(畸变率为12.97％),显著高于对照组(7.85％)。实验组脆性部位的表达率为8.3％,而对照组为4.88％,二者比较差异亦具有显著意义(x~2=8.34,P<0.01)。提示白血病患者存在着明显的染色体不稳定性。
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| 关 键 词： | 染色体畸变 白血病 染色体 |
STUDY ON CHROMOSOME FRAGILE SITES OF PATIENTS WITH LEUKEMIAS |
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| Yan Mingren,et al.STUDY ON CHROMOSOME FRAGILE SITES OF PATIENTS WITH LEUKEMIAS[J].Journal of Weifang Medical College,1992,14(2):84-86. |
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| Authors: | Yan Mingren |
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| Abstract: | The chromosome instability and fragile sites expression of peripheral lymphacytes were studied in 10 cases of leukemic patients and 9 control subjects. Using TC199 medium containing 3% fetal bovine serun. The results showed that the chromosome aberration rate of the patients(12.97%) was significantly higher than the nomal perssons(7.2%)(P<0.01). G-banding analysis in situ revealed that 76 breaks and gaps were consistant with the common fragile sites. |
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| Keywords: | chromosome aberrations chromosome fragile site oncogene leukemia |
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