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慢性心房重构犬心房肌细胞内游离钙离子浓度的变化
引用本文:王健,宋书凯,李敬田,马长虹.慢性心房重构犬心房肌细胞内游离钙离子浓度的变化[J].潍坊医学院学报,2006,28(5):347-348.
作者姓名:王健  宋书凯  李敬田  马长虹
作者单位:1. 潍坊医学院附属潍坊市人民医院心血管内科,山东,潍坊,261041
2. 潍坊医学院附属医院心内科
3. 潍坊市第二人民医院
摘    要:目的 观察慢性心房重构犬心房肌细胞内游离钙变化,探讨慢性心房重构分子机制。方法 实验犬随机分为两组:对照组,起搏组。起搏组利用快速心房起搏(ATP)建立慢性心房重构模型,用激光共聚焦显微镜技术,以Flou-3/AM作为钙指示剂,测定两组犬心房肌细胞内游离钙浓度。结果 起搏组犬心房肌细胞内游离钙离子浓度较对照组明显增加(P〈0.01)。结论 慢性心房重构犬心房肌细胞存在钙超载,提示钙超负荷是慢性心房重构分子机制。

关 键 词:心房重构  钙超载  房颤
文章编号:1004-3101(2006)05-0347-02
收稿时间:2006-09-10
修稿时间:2006年9月10日

Intracellular Free Ca2+ Concentration in Dog Atrial Muscle Cell of Chronic Atrial Remo Deling
WANG Jian,SONG Shu-kai,LI Jing-tian,MA Chang-hong.Intracellular Free Ca2+ Concentration in Dog Atrial Muscle Cell of Chronic Atrial Remo Deling[J].Journal of Weifang Medical College,2006,28(5):347-348.
Authors:WANG Jian  SONG Shu-kai  LI Jing-tian  MA Chang-hong
Abstract:Objective To observe intracellular free Ca~(2+) concentration in dog atrial muscle cell of chronic atrial remodeling and study the molecular mechanism of chronic atrial remodeling.Methods Dogs in the experiment were divided into two groups:control group and pacing group.Models of chronic atrial remodeling was set up induced by rapid atrial pacing in pacing group.Intracellular free Ca~(2+) concentration was measured in dog atrial muscle of two groups with laser confocal microscopy and with Flou-3/AM as calcium indicator.Results Intracellular free Ca~(2+) concentration in dog atrial muscle cell of pacing group increased significantly than that of control group(P<0.01).Conclusion There is calcium overload in dog atrial muscle cell of chronic atrial remodeling hinting that calcium overload is involved in the molecular mechanism of chronic atrial remodeling.
Keywords:Atrial remodeling  Calcium overload  Atrial fibrillation
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