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慢性胃炎证候与幽门螺杆菌及Bcl-2蛋白的相关性研究
引用本文:高碧珍,兰启防,李灿东,林雪娟.慢性胃炎证候与幽门螺杆菌及Bcl-2蛋白的相关性研究[J].福建中医学院学报,2003,13(6):1-3.
作者姓名:高碧珍  兰启防  李灿东  林雪娟
作者单位:1. 福建中医学院,福建,福州,350003
2. 厦门市湖里医院,福建,厦门,361000
基金项目:福建省教育厅科技三项费用资助项目 ( K0 2 0 87)
摘    要:研究慢性胃炎证候与幽门螺杆菌 ( HP)及胃粘膜 Bcl-2蛋白的相关性 ,探讨证候形成机理。选择慢性浅表性胃炎患者 89例为对象 ,其中湿热蕴脾证 5 3例 ,脾胃气虚证 3 6例 ,1 0名健康人为对照。采用辨证、HP、胃粘膜 Bcl-2蛋白等指标进行研究。结果 :1 HP感染率湿热蕴脾组显著高于对照组和脾胃气虚组 ;2湿热蕴脾组和脾胃气虚组 Bcl-2有不同程度的异常表达 ,以脾胃气虚组为高 ,但与 HP感染率的相关性未能得到证实。结论 :脾胃虚实证候与 HP感染存在相关性 ,湿热是 HP生长、繁殖的病理基础 ;细胞凋亡相关蛋白 Bcl-2与证候形成有关。

关 键 词:辨证分型  幽门螺杆菌  细胞凋亡  Bcl-2  慢性胃炎
文章编号:1004-5627(2003)06-0001-03
修稿时间:2003年9月29日

Study on Correlation Among TCM Syndromes,Helicobacter Pylori and Bcl-2 Protein in Chronic Gastritis
GAO Bi zhen,LAN Qi fang\,LI Can dong\,et al\.Study on Correlation Among TCM Syndromes,Helicobacter Pylori and Bcl-2 Protein in Chronic Gastritis[J].Journal of Fujian College of Traditional Chinese Medicine,2003,13(6):1-3.
Authors:GAO Bi zhen  LAN Qi fang\  LI Can dong\  et al\
Institution:GAO Bi zhen+1,LAN Qi fang\+2,LI Can dong\+3,et al\,
Abstract:To study the correlation among TCM syndromes,helicobacter pylori (HP)and gastric mucosa Bcl 2 protein(GMBP),and to study the mechanism of TCM syndromes development,the indexes,such as TCM syndromes,HP and GMBP,were observed in 89 cases of chronic superficial gastritis(including G1-53 cases of spleen damp heat syndrome,G2-36 cases of syndrome QI deficiency of spleen and stomach)in comparison with 10 normal subjects.The results showed that the HP infection rates in G1 were higher than that in G2;There were different extent of abnormal express of Bcl 2 in two groups,and G2 was little higher,but there was not obvious correlation with HP infection.It indicates that there is correlation between TCM syndromes,deficiency and excess of spleen and stomach,and HP infection;The damp heat is the pathological basis on HP development and proliferation;Apoptosis related protein Bcl 2 is related to TCM syndromes development.
Keywords:differentiation syndromes  helicobacter pylori  apoptosis  Bcl 2  chronic gastritis
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